N,N,2,2,4-五甲基戊酰胺 | 93762-17-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N,N,2,2,4-五甲基戊酰胺
• 英文名称: N,N,2,2,4-Pentamethylvaleramide
• 英文别名: N,N,2,2,4-pentamethylpentanamide
• CAS: 93762-17-5
• 化学式: C₁₀H₂₁NO
• 分子量: 171.283
• InChiKey: DDOZFENEPXDBJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-(三氟甲基)苯基)-1H-吡咯-2,5-二酮 、 N,N,2,2,4-五甲基戊酰胺 在 5-(trifluoromethyl)pyridine-3-sulfonic acid 、 silver(I) acetate 、 palladium diacetate 作用下， 反应 24.0h， 以22.4 mg的产率得到
  参考文献：
  名称：

  钯催化的 [3+2] 环加成反应通过二重 1,3-C(sp3)–H 活化

  摘要：

  环加成反应提供了一种以高度收敛和立体选择性方式构建环系统的快速途径。然而，要发生典型的环加成反应，需要在底物中安装多个反应性官能团（π 键、离去基团等），这会影响环加成反应的整体效率或范围。在这里，我们报告了钯催化的 [3+2] 反应，该反应利用两倍 C(sp3)-H 活化生成用于正式环加成的三碳单元。脂肪族酰胺/马来酰亚胺插入的初始 -C(sp3)-H 激活触发重新铺设的第二次 C(sp3)-H 激活以完成正式的 [3+2] 环加成。成功的关键是使用弱配位酰胺作为导向基团，已经报道了具有更强配位导向基团的不希望的 Heck 或烷基化途径。吡啶-3-磺酸配体的使用对于促进酰胺导向的 C(sp3)-H 活化步骤也至关重要。该方法与多种酰胺底物兼容，包括内酰胺，可产生螺双环产物。[3+2] 产物还显示出经过还原去对称化过程，以获取具有多个立体中心的手性环戊烷，并具有出色的对映选择性。

  DOI：

  10.1021/jacs.0c08290

文献信息

• 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS
  申请人：Hutchinson Howard John

  公开号：US20070219206A1

  公开（公告）日：2007-09-20

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

  本文描述了一些化合物和含有这些化合物的制药组合物，这些化合物可以调节5-脂氧合酶激活蛋白（FLAP）的活性。本文还描述了使用这种FLAP调节剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他依赖于白三烯或介导白三烯的疾病或病症。
• Near infrared absorbing composition, near infrared cut filter, method of manufacturing near infrared cut filter, solid image pickup element, camera module, and image display device
  申请人：FUJIFILM Corporation

  公开号：US10989846B2

  公开（公告）日：2021-04-27

  Provided are a near infrared absorbing composition with which a cured film having excellent solvent resistance and thermal shock resistance can be manufactured, a near infrared cut filter, a method of manufacturing a near infrared cut filter, a solid image pickup element, a camera module, and an image display device. The near infrared absorbing composition includes: a resin A that satisfies the following condition a1; an infrared absorber B; and a solvent D. At least the resin A has a crosslinking group, or the near infrared absorbing composition further includes a compound C having a crosslinking group that is different from the resin A. condition a1: in a case where the resin A does not have a crosslinking group, a glass transition temperature of the resin A measured by differential scanning calorimetry is 0° C. to 100° C., and in a case where the resin A has a crosslinking group, a glass transition temperature of a resin having a structure in which a portion which forms a crosslinking bond in the crosslinking group of the resin A is substituted with a hydrogen atom is 0° C. to 100° C., the glass transition temperature being measured by differential scanning calorimetry.

  本发明提供了一种近红外吸收组合物、一种近红外切割滤光片、一种近红外切割滤光片的制造方法、一种固体图像拾取元件、一种照相机模块和一种图像显示装置。近红外吸收组合物包括：满足以下条件 a1 的树脂 A；红外线吸收剂 B；以及溶剂 D。至少树脂 A 具有交联基团，或者近红外吸收组合物进一步包括具有不同于树脂 A 的交联基团的化合物 C。 条件 a1：在树脂 A 不具有交联基团的情况下，通过差示扫描量热法测量的树脂 A 的玻璃化转变温度为 0° C 至 100°C；在树脂 A 具有交联基团的情况下，通过差示扫描量热法测量的具有如下结构的树脂的玻璃化转变温度为 0° C 至 100°C：在树脂 A 的交联基团中形成交联键的部分被氢原子取代。
• Silicone hydrogel composition
  申请人：PEGAVISION CORPORATION

  公开号：US11046802B2

  公开（公告）日：2021-06-29

  The present invention provides a silicone hydrogel composition. The silicone hydrogel composition includes a water-soluble silicone macromere, a hydrophilic monomer, a crosslinker, an initiator and an organic solvent. The water-soluble silicone macromere, the hydrophilic monomer, the crosslinker and the initiator is respectively in the amount of 50-80 wt %, 19-50 wt %, 0.1-1.5 wt % and 0.1-1 wt % based on the total weight of the silicone hydrogel composition.

  本发明提供了一种硅酮水凝胶组合物。该有机硅水凝胶组合物包括水溶性有机硅大分子、亲水单体、交联剂、引发剂和有机溶剂。水溶性有机硅大分子、亲水单体、交联剂和引发剂的用量分别为有机硅水凝胶组合物总重量的 50-80%、19-50%、0.1-1.5% 和 0.1-1%。
• PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1
  申请人：AILERON Therapeutics, Inc.

  公开号：US20170107252A1

  公开（公告）日：2017-04-20

  The disclosed peptidomimetic macrocycles modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which MCL-1 is over-expressed, such as cancer. In particular, MCL-1-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by MCL-1 over-expression or hyper-activation.
• SILICONE HYDROGEL COMPOSITION
  申请人：PEGAVISION CORPORATION

  公开号：US20200291160A1

  公开（公告）日：2020-09-17

  The present invention provides a silicone hydrogel composition. The silicone hydrogel composition includes a water-soluble silicone macromere, a hydrophilic monomer, a crosslinker, an initiator and an organic solvent. The water-soluble silicone macromere, the hydrophilic monomer, the crosslinker and the initiator is respectively in the amount of 50-80 wt %, 19-50 wt %, 0.1-1.5 wt % and 0.1-1 wt % based on the total weight of the silicone hydrogel composition.