1-bromo-5,5-dimethyl-hex-2-ene | 467446-24-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 1-bromo-5,5-dimethyl-hex-2-ene
• 英文别名: 1-Bromo-5,5-dimethylhex-2-ene；1-bromo-5,5-dimethylhex-2-ene
• CAS: 467446-24-8
• 化学式: C₈H₁₅Br
• 分子量: 191.111
• InChiKey: DLSMILBKWXKWAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-bromo-5,5-dimethyl-hex-2-ene 、 benzyl 2-phenylpropanoate 在 lithium hexamethyldisilazane 、 地昔帕明 、 lithium iodide 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 Benzyl 2,7,7-trimethyl-2-phenyloct-4-enoate
  参考文献：
  名称：

  Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors

  摘要：

  A series of gem-dialkyl naphthalenone derivatives with varied alkyl substitutions were synthesized and evaluated according to their structure-activity relationship. This investigation led to the discovery of potent inhibitors of the hepatitis C virus at low nanomolar concentrations in both enzymatic and cell-based HCV genotype la assays. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.088
• 作为产物：
  描述：

  5,5-dimethyl-hex-1-en-3-ol 在 二溴亚砜 、 1,5-已二烯 作用下， 生成 1-bromo-5,5-dimethyl-hex-2-ene
  参考文献：
  名称：

  Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors

  摘要：

  A series of gem-dialkyl naphthalenone derivatives with varied alkyl substitutions were synthesized and evaluated according to their structure-activity relationship. This investigation led to the discovery of potent inhibitors of the hepatitis C virus at low nanomolar concentrations in both enzymatic and cell-based HCV genotype la assays. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.088

文献信息

• Anti-infective agents
  申请人：Hutchinson K. Douglas

  公开号：US20050107364A1

  公开（公告）日：2005-05-19

  Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

  具有该公式的化合物是丙型肝炎（HCV）聚合酶抑制剂。还公开了一种用于抑制丙型肝炎（HCV）聚合酶的组成和方法，用于制造这些化合物的过程，以及在这些过程中使用的合成中间体。
• ALKYL-SUBSTITUTED ALLYL CARBONYL METAL COMPLEXES AND USE THEREOF FOR PREPARING DIELECTRIC THIN FILMS
  申请人：Odedra Rajesh

  公开号：US20130041170A1

  公开（公告）日：2013-02-14

  Organometallic complexes and use thereof in thin film deposition, such as CVD and ALD are provided herein. The organometallic complexes are (alkyl-substituted η 3 -allyl)(carbonyl)metal complexes.

  本文提供了有机金属配合物及其在薄膜沉积中的应用，如CVD和ALD。这些有机金属配合物是（烷基取代的η3-烯丙基）（羰基）金属配合物。
• Anti-Infective Agents
  申请人：Hutchinson Douglas K.

  公开号：US20080193413A1

  公开（公告）日：2008-08-14

  Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

  具有公式的化合物是丙型肝炎（HCV）聚合酶抑制剂。还公开了一种用于抑制丙型肝炎（HCV）聚合酶的组合物和方法，制备化合物的过程以及用于该过程的合成中间体。
• HIGH MOLECULAR WEIGHT ALKYL-ALLYL COBALTTRICARBONYL COMPLEXES AND USE THEREOF FOR PREPARING DIELECTRIC THIN FILMS
  申请人：Sigma-Aldrich Co. LLC

  公开号：EP2462148A1

  公开（公告）日：2012-06-13
• US7378414B2
  申请人：——

  公开号：US7378414B2

  公开（公告）日：2008-05-27