N,N-dipropylpalmitamide | 57383-11-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N-dipropylpalmitamide
• 英文别名: N,N-di-n-propylhexadecanamide；N,N-dipropylhexadecanamide
• CAS: 57383-11-6
• 化学式: C₂₂H₄₅NO
• 分子量: 339.605
• InChiKey: VDQVFTRTOJJOGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  24
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• A METHOD OF TREATING PERIPHERAL INFLAMMATORY DISEASE
  申请人：Dublin City University

  公开号：EP3095444A1

  公开（公告）日：2016-11-23

  An active for use in the treatment or inhibition of an inflammatory disease associated with over-activation of Toll-like Receptor 4 (TLR4), Toll-like Receptor 2 (TLR2) and Myeloid differentiating protein 88 (Myd88) adaptor-like protein (Mal) while maintaining a subject's ability to respond normally to a pathogen, in which the active is an oleamide or a derivative thereof.

  一种用于治疗或抑制与Toll样受体4（TLR4）、Toll样受体2（TLR2）和髓样分化蛋白88（Myd88）适配样蛋白（Mal）过度激活相关的炎症性疾病，并同时保持受试者对病原体正常反应能力的活性物质为油酰胺或其衍生物。
• Penetration enhancers for transdermal delivery of systemic agents
  申请人：WHITBY RESEARCH, Inc.

  公开号：EP0268220A2

  公开（公告）日：1988-05-25

  This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula wherein R¹ and R² are independently selected from the group consisting of alkyl radicals and cycloalkyl radicals comprising from 1 to 20 carbon atoms and R is selected from the group consisting of alkyl radicals and cycloalkyl radicals comprising from 1 to 30 carbon atoms; provided, however, that the total number of carbon atoms in said compound is 15 or more and the total number of carbon atoms in R¹ and R² is 5 or more.

  本发明涉及一种在透皮装置或制剂中通过人和动物的皮肤或粘膜施用包括治疗剂在内的全身活性制剂的方法，该方法包括与所述全身制剂一起局部施用有效量的具有结构式的膜渗透促进剂 其中 R¹ 和 R² 独立地选自由 1 至 20 个碳原子的烷基和环烷基组成的组，R 选自由 1 至 30 个碳原子的烷基和环烷基组成的组；但前提是所述化合物中的碳原子总数为 15 个或更多，且 R¹ 和 R² 中的碳原子总数为 5 个或更多。
• EP0329669A4
  申请人：——

  公开号：EP0329669A4

  公开（公告）日：1989-12-12
• COMPOSITIONS COMPRISING N,N-DIALKYLALKANAMIDES AND THEIR USES
  申请人：Whitby Research Incorporated

  公开号：EP0329669A1

  公开（公告）日：1989-08-30
• A METHOD FOR TREATING PERIPHERAL INFLAMMATORY DISEASE
  申请人：Dublin City University

  公开号：EP3297621A1

  公开（公告）日：2018-03-28