N-alanyl-leucine amide | 38689-32-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-alanyl-leucine amide
• 英文别名: N-Alanyl-leucin-amid；2-(2-aminopropanoylamino)-4-methylpentanamide
• CAS: 38689-32-6
• 化学式: C₉H₁₉N₃O₂
• 分子量: 201.269
• InChiKey: YXGZZYSVTBYGNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  98.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-4-甲基戊酰胺 在 氨 、 水 作用下， 生成 N-alanyl-leucine amide
  参考文献：
  名称：

  Bergell; v. Wuelfing, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1910, vol. 65, p. 491

  摘要：

  DOI：

文献信息

• ERYTHROPOIETIN-DERIVED PEPTIDE, PREPARATION METHOD AND USE THEREOF
  申请人：Zhongshan Hospital, Fudan University

  公开号：US20210171595A1

  公开（公告）日：2021-06-10

  An erythropoietin-derived peptide having an amino acid sequence as shown in SEQ ID NO: 1. A method for preparing the above-described erythropoietin-derived peptide. Also provided is the use of the above-described erythropoietin-derived peptide for the preparation of a medicament for treating nerve cell damage. Also provided is the use of the above-described erythropoietin-derived peptide for the preparation of a medicament for treating hypoxic brain damage. Also provided is the use of the above-described erythropoietin-derived peptide for the preparation of a medicament for treating epilepsy. The novel EPO-derived peptide of the present invention has a small molecular weight and can penetrate the blood-brain barrier. Moreover, it is a small-molecule polypeptide derived from a functional protein in the human body, having an extremely small side effect to the human body compared with other developed and synthesized drugs, thereby it has a good clinical application prospect.
• Bergell; v. Wuelfing, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1910, vol. 65, p. 491
  作者：Bergell、v. Wuelfing

  DOI：——

  日期：——