2-[3-Bromo-5-ethoxy-4-[(2-methylphenyl)methoxy]phenyl]-1,3-thiazolidin-3-ium-4-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[3-Bromo-5-ethoxy-4-[(2-methylphenyl)methoxy]phenyl]-1,3-thiazolidin-3-ium-4-carboxylate
• 化学式: C20H22BrNO4S
• mdl: MFCD07606904
• 分子量: 452.4
• InChiKey: MKHFUVFCQDZCDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] IDENTIFICATION OF STABILIZERS OF MULTIMERIC PROTEINS<br/>[FR] IDENTIFICATION DE STABILISANTS DE PROTÉINES MULTIMÉRIQUES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2011140333A1

  公开（公告）日：2011-11-10

  Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and therby decreasing aggegate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.

  本文披露了一些化合物及其组合物，可用于增加TTR四聚体的稳定性，减少其错误折叠和形成聚集物的倾向。本文还提供了使用这些化合物和组合物来增加TTR稳定性并从而减少TTR聚集物形成的方法。本文还披露了用于筛选增加TTR稳定性的候选化合物的方法。本文还披露了一种包括TTR结合化合物通过连接物连接到靶向基团的异双功能化合物，用于破坏靶蛋白的蛋白-蛋白相互作用。
• Identification of Stabilizers of Multimeric Proteins
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20150126532A1

  公开（公告）日：2015-05-07

  Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and thereby decreasing aggregate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.

  本文公开了一些化合物及其组合物，可用于增加TTR四聚体的稳定性，减少其错折和聚集的倾向。本文还提供了使用这些化合物和组合物增加TTR稳定性、从而减少TTR聚集形成的方法。本文还公开了筛选候选化合物以增加TTR稳定性的方法。本文还公开了异双功能化合物，其中包括一个TTR结合化合物通过连接子连接到一个靶向基团上，用于破坏目标蛋白质的蛋白质相互作用。
• Identification of stabilizers of multimeric proteins
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10039726B2

  公开（公告）日：2018-08-07

  Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and therby decreasing aggegate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PP is of a target protein.

  本文公开的化合物及其组合物可用于提高 TTR 四聚体的稳定性，降低其折叠错误和形成聚集体的倾向。本文还提供了使用这些化合物和组合物提高 TTR 的稳定性并从而减少 TTR 形成聚集体的方法。本文还公开了筛选提高 TTR 稳定性的候选化合物的方法。本文还公开了杂多功能化合物，其中包括通过连接体与靶向分子连接的 TTR 结合化合物，用于破坏靶蛋白的 PP。
• US8877795B2
  申请人：——

  公开号：US8877795B2

  公开（公告）日：2014-11-04
• US9308209B2
  申请人：——

  公开号：US9308209B2

  公开（公告）日：2016-04-12