CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT
申请人:Schering Corporation
公开号:EP1660443B1
公开(公告)日:2009-03-04
An efficient conversion of nitriles to amides: application in the synthesis of N,N-diethyl-m-toluamide (DEET™)
作者:Apurba Bhattacharya、Robert Erik Plata、Victor Villarreal、Savitha Muramulla、Jiejun Wu
DOI:10.1016/j.tetlet.2005.11.063
日期:2006.1
Arylnitriles react with magnesium amides to produce carboxamides in excellent yield. The method was applied for the preparation of the insect repellent DEET™.