α-phenylphosphonyl-β,γ-diphosphate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-phenylphosphonyl-β,γ-diphosphate
• 英文别名: [Hydroxy(phosphonooxy)phosphoryl]oxy-phenylphosphinic acid；[hydroxy(phosphonooxy)phosphoryl]oxy-phenylphosphinic acid
• 化学式: C₆H₉O₉P₃
• 分子量: 318.053
• InChiKey: YVHIQDNJWPMETP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  151
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  苯膦酸 在 N,N'-羰基二(1,2,4-三氮唑) 、 三正丁胺 、 三丁基焦磷酸铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 α-phenylphosphonyl-β,γ-diphosphate
  参考文献：
  名称：

  Synthesis of Non-Nucleoside Triphosphate Analogues, a New Type of Substrates for Terminal Deoxynucleotidyl Transferase

  摘要：

  A series of non-nucleoside triphosphate analogues were synthesized. In place of the nucleoside fragment, substituents bearing aromatic groups were introduced; the triphosphate component was replaced at alpha, beta, or gamma -positions by phosphonates. alpha-[2-N-(9-Fluorenylmethoxycarbonyl)aminoethylphosphonyl]-beta,gamma -difluoromethylenediphosphonate (IIc) revealed the best substrate properties toward terminal deoxynucleotidyl transferase.

  DOI：

  10.1080/15257770008045460

文献信息

• Synthesis of Non-Nucleoside Triphosphate Analogues, a New Type of Substrates for Terminal Deoxynucleotidyl Transferase
  作者：Andrey A. Arzumanov、Lyubov S. Victorova、Maxim V. Jasko

  DOI：10.1080/15257770008045460

  日期：2000.10

  A series of non-nucleoside triphosphate analogues were synthesized. In place of the nucleoside fragment, substituents bearing aromatic groups were introduced; the triphosphate component was replaced at alpha, beta, or gamma -positions by phosphonates. alpha-[2-N-(9-Fluorenylmethoxycarbonyl)aminoethylphosphonyl]-beta,gamma -difluoromethylenediphosphonate (IIc) revealed the best substrate properties toward terminal deoxynucleotidyl transferase.