Tert-butyl 4-diphenylphosphanyl-2-(diphenylphosphanylmethyl)pyrrolidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Tert-butyl 4-diphenylphosphanyl-2-(diphenylphosphanylmethyl)pyrrolidine-1-carboxylate
• 化学式: C₃₄H₃₇NO₂P₂
• 分子量: 553.6
• InChiKey: BFMKBYZEJOQYIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Tert-butyl 4-diphenylphosphanyl-2-(diphenylphosphanylmethyl)pyrrolidine-1-carboxylate 生成 4-diphenylphosphanyl-2-(diphenylphosphanyl-methyl)-pyrrolidine
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  Tert-butyl 4-(4-methylphenyl)sulfonyloxy-2-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine-1-carboxylate 、 sodium diphenylphosphide 生成 Tert-butyl 4-diphenylphosphanyl-2-(diphenylphosphanylmethyl)pyrrolidine-1-carboxylate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE
  申请人：——

  公开号：US20020133026A1

  公开（公告）日：2002-09-19

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  描述了一种通过新型合成制备5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代-四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺的改进工艺，其中将甲基氰乙酸酯在八个或更少的步骤中转化为所需产品，以及在该过程中使用的其他有价值的中间体。
• [EN] PROCESS FOR PREPARING SUBSTITUTED PHENYLALKANES<br/>[FR] PROCÉDÉ POUR PRÉPARER DES PHÉNYLALCANES SUBSTITUÉS
  申请人：MALLINCKRODT LLC

  公开号：WO2016007823A1

  公开（公告）日：2016-01-14

  The invention provides methods for preparing substituted phenylalkanes. In particular, the processes comprise reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction. The processes may be useful in the synthesis of tapentadol.

  该发明提供了制备取代苯基烷烃的方法。具体而言，这些方法包括通过不对称的1,4-加成反应，将苯基硼化合物与含α-β不饱和羰基的化合物反应。这些方法可能在tapentadol的合成中有用。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150210657A1

  公开（公告）日：2015-07-30

  A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P represents an optically active diphosphine, X represents an anionic group, and Ar represents an optionally substituted arylene group).

  一种制备光学活性胺化合物的方法，其特征在于在存在由通用式（1）或（2）表示的钌配合物的情况下，对一个丙半胱氨基双键进行不对称氢化（其中P代表光学活性二膦，X代表阴离子基团，Ar代表可选择取代的芳基基团）。
• [EN] METHOD FOR PRODUCING AN OPTICALLY ACTIVE NITRO COMPOUND<br/>[FR] PROCEDE DE PRODUCTION D'UN COMPOSE NITRO OPTIQUEMENT ACTIF
  申请人：CARREIRA ERICK M

  公开号：WO2004103951A1

  公开（公告）日：2004-12-02

  An optically active nitro compound having two hydrogen atoms on its α-cabon atom and having β-asymmetric carbon atom can be produced by making α, β-unsaturated nitroolefin having a hydrogen atom on its α-cabon atom react with at least two organosilicon compounds having at lest one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex, or react with an organosilicon compound having at least one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex and water.

  具有两个氢原子的α-碳原子和β-手性碳原子的光学活性硝基化合物可以通过使具有α-碳原子上的氢原子的α，β-不饱和硝基烯烃与至少两个分子中至少有一个硅-氢键的有机硅化合物在存在不对称铜配合物的情况下反应，或者在存在不对称铜配合物和水的情况下，使具有至少一个硅-氢键的有机硅化合物与α-碳原子上的氢原子反应来制备。
• Process for preparing oprtically active trimethyllactic acid and its ester
  申请人：——

  公开号：US20020035271A1

  公开（公告）日：2002-03-21

  The invention relates to a novel process for preparing optically active trimethyllactic acid and/or its esters by catalytic hydrogenation of trimethylpyruvic acid and/or its esters in the presence of noble metal complex catalysts containing phosphorus ligands.

  这项发明涉及一种新的制备光学活性三甲基乳酸和/或其酯的工艺，通过在含有磷配体的贵金属配合物催化剂存在下对三甲基丙酮酸和/或其酯进行催化氢化来实现。