Diethyl 2-(3-chloro-2-phenylmethoxypropyl)propanedioate | 1356087-23-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Diethyl 2-(3-chloro-2-phenylmethoxypropyl)propanedioate
• CAS: 1356087-23-4
• 化学式: C₁₇H₂₃ClO₅
• 分子量: 342.82
• InChiKey: BJYAQFFIGNWMAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Diethyl 2-(3-chloro-2-phenylmethoxypropyl)propanedioate 反应 2.0h， 生成 3-苄氧基环丁烷-1,1-二甲酸二乙酯
  参考文献：
  名称：

  WO2007/62332

  摘要：

  公开号：
• 作为产物：
  描述：

  1-((1-溴-3-氯丙烷-2-基氧基)甲基)苯 、 丙二酸二乙酯 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 Diethyl 2-(3-chloro-2-phenylmethoxypropyl)propanedioate
  参考文献：
  名称：

  WO2007/62332

  摘要：

  公开号：

文献信息

• Novel Intermediates and Their Use
  申请人：Liu Peng

  公开号：US20080275251A1

  公开（公告）日：2008-11-06

  The invention is directed to novel acyloxy imidazole intermediates useful for making certain C-14 oxycarbonyl carbamate pleuromutilin derivatives. The invention is further directed to a process for making such acyloxy imidazole intermediates and to a process for making C-14 oxycarbonyl carbamate pleuromutilin derivatives using such acyloxy imidazole intermediates.

  本发明涉及新型酰氧基咪唑中间体，可用于制备特定的C-14氧羰基氨基甲酸酯类木鳖菌素衍生物。本发明还涉及制备这种酰氧基咪唑中间体的过程，以及使用这种酰氧基咪唑中间体制备C-14氧羰基氨基甲酸酯类木鳖菌素衍生物的过程。
• WO2007/62333
  申请人：——

  公开号：——

  公开（公告）日：——
• Pleuromutilin Derivatives and Its Use
  申请人：Igo David H.

  公开号：US20080269342A1

  公开（公告）日：2008-10-30

  The invention is directed to the L-tartrate salt of trans-3-aminocyclobutyl (1S,2R,3S,4S,6R,7R,8,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA.) Compound IA is useful for the treatment of a variety of diseases and conditions, such as respiratory tract and skin and skin structure infections. Accordingly, the invention is further directed to pharmaceutical compositions comprising Compound IA. The invention is still further directed to methods of treating respiratory tract and skin and skin structure infections using Compound IA or a pharmaceutical composition comprising Compound IA.
• [EN] NEW PLEUROMUTILIN DERIVATIVE AND ITS USE<br/>[FR] NOUVEAU DERIVE DE LA PLEUROMUTILINE ET SON UTILISATION
  申请人：GLAXO GROUP LTD

  公开号：WO2007062333A2

  公开（公告）日：2007-05-31

  [EN] The invention is directed to the L-tartrate salt of trans-3-aminocyclobutyl (lS,2R,3S,4S:,6R,7R,8R-,14R)-4-ethenyl-3-hydroxy-2,4,7, 14-tetramethyl-9- oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA.) Compound IA is useful for the treatment of a variety of diseases and conditions, such as respiratory tract and skin and skin structure infections. Accordingly, the invention is further directed to pharmaceutical compositions comprising Compound IA. The invention is still further directed to methods of treating respiratory tract and skin and skin structure infections using Compound IA or a pharmaceutical composition comprising Compound IA.
  [FR] La présente invention concerne le sel L-tartrate du trans-3-aminocyclobutyl (lS,2R,3S,4S:,6R,7R,8R-,14R)-4-éthényl-3-hydroxy-2,4,7, 14-tétraméthyl-9-oxotricyclo[5.4.3.01,8]tétradec-6-yl imido dicarbonate (composé IA). Le composé IA est utilisable pour le traitement de maladies et d'états variés tels que des infections des voies respiratoires et de la peau et des structures cutanées. En conséquence, l'invention concerne en outre des compositions pharmaceutiques comprenant le composé IA. L'invention concerne de plus des procédés de traitement d'infections des voies respiratoires et de la peau et des structures cutanées à l'aide du composé IA ou d'une composition pharmaceutique comprenant le composé IA.
• WO2007/62332
  申请人：——

  公开号：——

  公开（公告）日：——