diethylenetriaminetetraacetat

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethylenetriaminetetraacetat
• 英文别名: 2-[2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate
• 化学式: C₁₄H₂₀N₃O₁₀
• 分子量: 390.327
• InChiKey: QPCDCPDFJACHGM-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -6.6
• 重原子数：
  27
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  205
• 氢给体数：
  2
• 氢受体数：
  13

ADMET

毒理性

• 在妊娠和哺乳期间的影响

◉ 母乳喂养期间使用总结：母亲接受钆喷酸葡胺后，排入母乳中的钆含量不到给予婴儿允许量的1%。此外，由于钆喷酸葡胺口服吸收不良，它不太可能进入婴儿的血液循环或对哺乳婴儿产生任何不良反应。钆喷酸葡胺与一些肾功能不全患者的肾源性系统性纤维化病例有关。北美专业组织制定的指南指出，哺乳期母亲接受含钆对比剂后，不需要中断哺乳。 ◉ 对哺乳婴儿的影响：截至修订日期，未找到相关的已发布信息。 ◉ 对泌乳和母乳的影响：截至修订日期，未找到相关的已发布信息。

◉ Summary of Use during Lactation:Amounts of gadolinium excreted into breastmilk after maternal gadopentetate are less than 1% of the amount allowed to be given to infants. In addition, because gadopentetate is poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Gadopentetate has been associated with some cases of nephrogenic systemic fibrosis in patients with renal impairment. Guidelines developed by North American professional organizations state that breastfeeding need not be disrupted after a nursing mother receives a gadolinium-containing contrast medium. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)