1,1-Cyclopentanedicarboxamide | 480452-26-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,1-Cyclopentanedicarboxamide
• 英文别名: cyclopentane-1,1-dicarboxamide
• CAS: 480452-26-4
• 化学式: C₇H₁₂N₂O₂
• 分子量: 156.18
• InChiKey: BYGAVIIEJSUUHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] PROCESSES AND INTERMEDIATES FOR PREPARING A MACROCYCLIC PROTEASE INHIBITOR OF HCV<br/>[FR] PROCÉDÉS ET INTERMÉDIAIRES POUR LA PRÉPARATION D'UN INHIBITEUR DE PROTÉASE MACROCYCLIQUE DU VHC
  申请人：JANSSEN PHARMACEUTICALS INC

  公开号：WO2013041655A1

  公开（公告）日：2013-03-28

  Disclosed is a process for the preparation of a cinchonidine salt of formula (IV) via an aqueous solution of a racemic 4-hydroxy-1,2-cyclopentanedicarboxylic acid, which is subjected to cyclization without removing water, by the addition of a water- miscible organic solvent to the aqueous solution and, again without removing water, adding cinchonidine to the aqueous-organic solvent solution so as to obtain the cinchonidine salt of the lactone acid. The cinchonidine salt is allowd to crystallize so as to obtain the enantiomerically purified crystalline lactone acid cinchonidine salt (IV). The enantiomerically pure salt is an intermediate in the synthesis of HCV inhibitor compound of formula (I).

  揭示了一种制备奎宁啉盐（IV式）的过程，通过将外消旋4-羟基-1,2-环戊二羧酸的水溶液进行环化，无需去除水，向水溶液中加入水亲和性有机溶剂，再次无需去除水，将奎宁啉加入水-有机溶剂溶液中，以获得内酯酸奎宁啉盐。奎宁啉盐被允许结晶，以获得对映纯化的结晶内酯酸奎宁啉盐（IV式）。对映纯盐是合成HCV抑制剂化合物（I式）的中间体。
• Dicarboxamide derivatives
  申请人：Boehringer Markus

  公开号：US20060106016A1

  公开（公告）日：2006-05-18

  The invention is concerned with novel dicarboxamide derivatives of formula (I) wherein A, B, R c , D and E are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.

  这项发明涉及式(I)的新颖二羧酰胺衍生物，其中A、B、Rc、D和E如描述和索赔中所定义，并且其生理上可接受的盐。这些化合物抑制凝血因子Xa，可用作药物。
• [EN] CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS<br/>[FR] PYRIMIDINES INHIBITRICES DE CHK-, PDK- ET DE AKT, PRODUCTION ET UTILISATION DE CES COMPOSES COMME AGENTS PHARMACEUTIQUES
  申请人：SCHERING AG

  公开号：WO2004048343A1

  公开（公告）日：2004-06-10

  This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.

  这项发明涉及通式（I）的嘧啶衍生物作为激酶抑制剂，它们的生产以及它们作为治疗各种疾病的药物的用途。
• [EN] PROCESSES AND INTERMEDIATES FOR PREPARING A MACROCYCLIC PROTEASE INHIBITOR OF HCV<br/>[FR] PROCÉDÉS ET INTERMÉDIAIRES DE PRÉPARATION D'UN INHIBITEUR DE PROTÉASE MACROCYCLIQUE DE HCV
  申请人：ORTHO MCNEIL JANSSEN PHARM

  公开号：WO2011113859A1

  公开（公告）日：2011-09-22

  A process for preparing [(1R,2R)-4-oxo-1,2-cyclopentanedicarboxylic acid II, by the resolution of racemic 4-oxo-1,2-cyclopentanedicarboxylic acid (V), said process comprising: (a) reacting 4-oxo-1,2-cyclopentanedicarboxylic acid (V) with brucine or (1R,2S)-(-)- ephedrine, thus preparing the bis-brucine or bis-(1R,2S)-(-)-ephedrine salt of (V), and (b) precipitating selectively the bis-brucine or bis-(1R,2S)-(-)-ephedrine salt of (1R,2R)-4-oxo-1,2-cyclopentanedicarboxylic acid II, while the bis-brucine or bis- (1R,2S)-(-)-ephedrine salt of [(1S,2S)-4-oxo-1,2-cyclopentanedicarboxylic acid stays in solution; (c) liberating the acid II by removal of brucine or (1R,2S)-(-)-ephedrine from the precipitated salt obtained in step (b).

  一种制备[(1R,2R)-4-氧代-1,2-环戊二羧酸II的方法，通过拆分外消旋4-氧代-1,2-环戊二羧酸(V)来实现，所述方法包括：(a)将4-氧代-1,2-环戊二羧酸(V)与布鲁辛或(1R,2S)-(-)-麻黄碱反应，从而制备(V)的双布鲁辛盐或双(1R,2S)-(-)-麻黄碱盐，并(b)在(V)的双布鲁辛盐或双(1R,2S)-(-)-麻黄碱盐中选择性地沉淀[(1R,2R)-4-氧代-1,2-环戊二羧酸II的盐，同时(V)的双布鲁辛盐或双(1R,2S)-(-)-麻黄碱盐保持在溶液中；(c)通过从步骤(b)中得到的沉淀盐中去除布鲁辛或(1R,2S)-(-)-麻黄碱来释放酸II。
• (Ethylene)-(propylene) - triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
  申请人：Schering AG

  公开号：US20030194371A1

  公开（公告）日：2003-10-16

  The invention relates to (ethylene)-(propylene)-triaminepentaacetic acid derivatives that are substituted on both the ethylene bridge and the propylene bridge, as well as conjugates of these compounds with biomolecules. The compounds and conjugates are suitable as agents for NMR diagnosis and radiodiagnosis as well as for radiotherapy.

  该发明涉及在乙烯桥和丙烯桥上取代的(乙烯)-(丙烯)-三胺五乙酸衍生物，以及这些化合物与生物分子的结合物。这些化合物和结合物适用于核磁共振诊断和放射诊断代理，以及放射治疗。