1-Fluoro-1-phenyl-2-methoxyethane | 79186-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Fluoro-1-phenyl-2-methoxyethane
• 英文别名: (1-Fluoro-2-methoxyethyl)benzene
• CAS: 79186-50-8
• 化学式: C₉H₁₁FO
• 分子量: 154.184
• InChiKey: WOBGOBCWZKILJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氟-2-苯基-乙醇 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以71%的产率得到1-Fluoro-1-phenyl-2-methoxyethane
  参考文献：
  名称：

  Synthese et proprietes d'ethers β-monofluores

  摘要：

  DOI：

  10.1016/s0022-1139(00)82301-5

文献信息

• Isolation and characterization of methyl hypofluorite (CH3OF)
  作者：Moshe Kol、Shlomo Rozen、Evan Appelman

  DOI：10.1021/ja00007a043

  日期：1991.3

  Methyl hypofluorite (CH 3 OF) has been prepared by the reaction of elemental fluorine with methanol in acetonitrile or propionitrile at low temperature. It was removed from the reaction mixture in a stream of nitrogen and purified by fractional distillation. The compound is moderately long-lived, although the liquid has exploded upon rapid warming. The liquid compound has a freezing point of about

  次氟酸甲酯 (CH 3 OF) 是通过元素氟与甲醇在乙腈或丙腈中在低温下反应制备的。在氮气流中将其从反应混合物中除去并通过分馏纯化。该化合物的寿命适中，尽管这种液体在快速升温时会发生爆炸。液体化合物的凝固点约为 -142°C，蒸气压测量表明正常沸点为 -32.6±0.9°C，蒸发焓为 23.37±0.26 kJ/mol。蒸气的红外光谱与分子与 CH 3 OH 和 CF 3 OF 同构。该化合物还通过质谱和 1 H、 19 F 和 13 C NMR 光谱进行了表征。
• The Chemistry of Methyl Hypofluorite: Its Reactions with Various Unsaturated Centers
  作者：Shlomo Rozen、Eyal Mishani、Moshe Kol、Iris Ben-David

  DOI：10.1021/jo00094a047

  日期：1994.7

  Methyl hypofluorite was until recently grouped as a hypothetical member of those smallest organic molecules which had not been synthesized. Passing F-2 through a solution of methanol in MeCN or PrCN resulted in its successful preparation. MeOF is an unique reagent, since it generates the novel electrophilic methoxylium moiety in contrast to the much more common methoxide group. This hypofluorite was reacted with several types of olefins including benzylic, cyclic, bicyclic, straight chain, and steroidal ones. In most cases the regioselectivity is very good, reflecting the unique polarization of the reagent: MeO(delta+)F(delta-). The stereoselectivity tends to be less emphasized, but usually anti addition is dominant.
• KOL, MOSHE;ROZEN, SHLOMO;APPELMAN, EVAN, J. AMER. CHEM. SOC., 113,(1991) N, C. 2648-2651
  作者：KOL, MOSHE、ROZEN, SHLOMO、APPELMAN, EVAN

  DOI：——

  日期：——
• BAKLOUTI A.; CHAABOUNI M. M., J. FLUOR. CHEM., 1981, 18, NO 1, 45-56
  作者：BAKLOUTI A.、 CHAABOUNI M. M.

  DOI：——

  日期：——
• Synthese et proprietes d'ethers β-monofluores
  作者：A. Baklouti、M.M. Chaabouni

  DOI：10.1016/s0022-1139(00)82301-5

  日期：1981.7