(5-methyl-2-furyl)diphenylphosphine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5-methyl-2-furyl)diphenylphosphine
• 英文别名: (5-Methylfuran-2-yl)-diphenylphosphane
• 化学式: C₁₇H₁₅OP
• 分子量: 266.279
• InChiKey: VAYFLMFWAIFHJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (5-methyl-2-furyl)diphenylphosphine 在 sodium methylate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 2.67h， 生成 1-[(5-methylfuran-2-yl)diphenylphosphonio]-2-oxo-2-phenyl-1-(phenyliodonio)ethanide tetrafluoroborate
  参考文献：
  名称：

  呋喃基取代的混合鏻-碘鎓叶立德在合成退火含磷杂环化合物中的应用

  摘要：

  稳定的呋喃基取代的鏻-碘鎓叶立德与末端乙炔之间的光化学反应导致形成新的含磷杂环化合物。对于 2-呋喃基取代的叶立德的杂环化，我们观察到前所未有的亲电同向攻击碳阳离子中间体中呋喃环的 α 位置，通过螺中间体导致重排产物在呋喃环。

  DOI：

  10.1002/ejoc.201500876
• 作为产物：
  描述：

  2-甲基呋喃 、 二苯基氯化膦 在 dilithium tetrabutylmagnesate 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以39%的产率得到(5-methyl-2-furyl)diphenylphosphine
  参考文献：
  名称：

  Deprotonation of furans using lithium magnesates

  摘要：

  Furan was deprotonated on treatment with 1/3 equiv of Bu3MgLi in THF at rt. The lithium arylmagnesate formed was either trapped with electrophiles or involved in a palladium-catalyzed cross-coupling reaction with 2-bromopyridine. The highly coordinated magnesate Bu4MgLi2 (1/3 equiv) proved to be a better deprotonating agent than Bu3MgLi; the monitoring of the reaction using NMR spectroscopy showed that the deprotonation of furan at rt required 2 h whereas the subsequent electrophilic trapping was instantaneous. The method was extended to benzofuran, allowing its functionalization at C2 in high yields. The deprotonation of 2-methylfuran and lithium furfurylalkoxide at C5 turned out to be difficult, requiring either long reaction times or higher temperatures. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.09.066

文献信息

• Process for the partial hydrogenation of fatty acid esters
  申请人：Papadogianakis Georgios

  公开号：US20100022664A1

  公开（公告）日：2010-01-28

  Suggested is a process for the manufacture of unsaturated fatty acid alkyl esters or glycerides having a total content of C 18:1 of about 30 to about 80 Mol-% by partial hydrogenation of unsaturated fatty acid esters having a total content of (C18:2+C18:3) of at least 65 Mol-%—calculated on the total amount of C18 moieties in the ester—which is characterised in that the hydrogenation is conducted in an aqueous/organic two phase system in the presence of a water soluble catalyst consisting of a Group VIII metal and a hydrophilic ligand.