7-[3-(4-Fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyheptanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 7-[3-(4-Fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyheptanoic acid
• 化学式: C₂₄H₂₈FNO₄
• 分子量: 413.5
• InChiKey: MVPCJBDHTUCOBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  82.7
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• PROCESS FOR PREPARATING ENANTIOMERICALLY PURE FLUVASTATIN SODIUM AND A NOVEL POLYMORPHIC FORM THEREOF
  申请人：Ranbaxy Laboratories Limited

  公开号：EP1817027A2

  公开（公告）日：2007-08-15
• IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS
  申请人：CAMP4 THERAPEUTICS CORPORATION

  公开号：US20210254056A1

  公开（公告）日：2021-08-19

  The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.
• [EN] A PROCESS FOR SYNTHESIS OF LARGE PARTICLE SIZE STATIN COMPOUNDS.<br/>[FR] PROCESSUS DE SYNTHESE DE COMPOSES STATINE A PARTICULES DE GRANDE TAILLE
  申请人：MOREPEN LAB LTD

  公开号：WO2006048893A2

  公开（公告）日：2006-05-11

  [EN] This invention discloses a process for synthesis of with large size statin compounds comprising adding solution of desired statin compound either crystalline or amorphous form, optionally obtained from, their intermediates by known methods, in organic solvent to anti-solvent, under stirring, optionally the solvent was being evaporated, isolating the title compound by centrifugation followed by drying under vacuum. Specifically the process was directed to the synthesis of Atorvastatin calcium and Fluvastatin Sodium.
  [FR] La présente invention concerne un processus de synthèse de composés statine à particules de grande taille qui consiste à ajouter une solution du composé statine souhaité de forme cristalline ou de forme amorphe, éventuellement obtenu de leurs intermédiaires par des procédés connus, de solvant organiques en anti-solvant, par mélange, le solvant étant éventuellement évaporé, à isoler le composé cité par centrifugation suivie par le séchage sous vide. Ce processus est plus particulièrement destiné à la synthèse du calcium d'atorvastatine et du sodium de fluvastatine.
• [EN] PROCESS FOR PREPARATING ENANTIOMERICALLY PURE FLUVASTATIN SODIUM AND A NOVEL POLYMORPHIC FORM THEREOF<br/>[FR] PROCEDES POUR PREPARER DU SODIUM DE FLUVASTATINE ENANTIOMERIQUEMENT PUR ET NOUVELLE FORME POLYMORPHE DE CELUI-CI
  申请人：RANBAXY LAB LTD

  公开号：WO2006035286A2

  公开（公告）日：2006-04-06

  The present invention provides processes for preparing enantiomerically pure fluvastatin sodium. The present invention also provides pharmaceutical compositions comprising the enantiomerically pure fluvastatin sodium for antagonizing HMG-CoA. In addition the present invention provides a novel polymorphic form of enantiomerically pure fluvastatin sodium.