N,N-二环己基吗啉-4-甲酰胺 | 84604-69-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: N,N-二环己基吗啉-4-甲酰胺
• 英文名称: N,N-Dicyclohexylmorpholine-4-carboxamide
• CAS: 84604-69-3
• 化学式: C₁₇H₃₀N₂O₂
• 分子量: 294.4
• InChiKey: TXQRHCGEVZOPQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Phosphonate Ester Derivatives and Methods of Synthesis Thereof
  申请人：Ware Roy W.

  公开号：US20120058976A1

  公开（公告）日：2012-03-08

  The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

  该披露描述了合成膦酸酯衍生物的方法。根据该披露的首选方法允许大规模制备高纯度的膦酸酯化合物。在一些实施例中，根据该披露的首选方法还允许在比以往用于制备这类化合物的方法更好的产率下制备膦酸酯衍生物，而无需使用色谱纯化方法。还披露了膦酸酯衍生物的形态形式。
• PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF
  申请人：Chimerix, Inc.

  公开号：US20150329575A1

  公开（公告）日：2015-11-19

  The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

  本公开说明了合成膦酸酯衍生物的方法。根据公开说明，首选方法允许大规模制备高纯度的膦酸酯化合物。在某些实施例中，根据公开说明的首选方法还允许在不使用色谱纯化方法的情况下制备膦酸酯衍生物，并且比以前用于制备此类化合物的方法产量更高。此外，还公开了膦酸酯衍生物的形态形式。
• COMPOSITION AND METHODS OF TREATING VIRAL INFECTIONS AND VIRAL INDUCED TUMORS
  申请人：Chimerix, Inc.

  公开号：EP2462152A1

  公开（公告）日：2012-06-13
• METHODS OF TREATING VIRAL ASSOCIATED DISEASES
  申请人：Chimerix, Inc.

  公开号：EP2493479A1

  公开（公告）日：2012-09-05
• Methods of Treating Orthopox Virus Infections and Associated Diseases
  申请人：Lanier Ernest R.

  公开号：US20110263536A1

  公开（公告）日：2011-10-27

  The present invention provides methods of treating diseases associated with at least one virus. The methods include administering a compound described in the invention in a therapeutically effective amount. According to some aspects of the present invention, the methods provide treatment of an orthopox virus infection or a disease related to orthopox virus.