2-methyl-N-propylpentanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methyl-N-propylpentanamide
• 化学式: C₉H₁₉NO
• mdl: MFCD02860561
• 分子量: 157.25
• InChiKey: VTXPRRUQVKYCGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] IN VIVO ENGINEERED CEREBLON PROTEIN<br/>[FR] PROTÉINE CEREBLON MODIFIÉE IN VIVO
  申请人：VIVIDION THERAPEUTICS INC

  公开号：WO2020140039A1

  公开（公告）日：2020-07-02

  Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3.

  本公开揭示了体内工程的 cereblon 蛋白质及其制备方法。体内工程的 cereblon 蛋白质可以包括在胱氨酸 287 处进行的特异性非自然发生修饰，如 SEQ ID NO:1 中所述，或者在 SEQ ID NO:2 或 3 中所述的胱氨酸 286 处进行的修饰，该修饰包括由体内 Michael 加成反应中外源 Michael 受体和在 SEQ ID NO:1 中所述的胱氨酸 287，或者在 SEQ ID NO:2 或 3 中所述的胱氨酸 286 之间产生的基团。
• Crosslinked Gels Comprising Polyalkyleneimines, And Their Uses As Medical Devices
  申请人：HyperBranch Medical Technology, Inc.

  公开号：US20210275718A1

  公开（公告）日：2021-09-09

  One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneimine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing photopolymerizable groups with ultraviolet or visible light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneimine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.
• US5224987A
  申请人：——

  公开号：US5224987A

  公开（公告）日：1993-07-06