N,N-二甲基-2-(2-丙氧基乙氧基)乙胺 | 100252-25-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: N,N-二甲基-2-(2-丙氧基乙氧基)乙胺
• 英文名称: dimethyl-[2-(2-phenoxy-ethoxy)-ethyl]-amine
• 英文别名: Dimethyl-[2-(2-phenoxy-aethoxy)-aethyl]-amin；N,N-dimethyl-2-(2-phenoxyethoxy)ethanamine
• CAS: 100252-25-3
• 化学式: C₁₂H₁₉NO₂
• 分子量: 209.288
• InChiKey: FVDGYOYBDHILKZ-UHFFFAOYSA-N

物化性质

• 沸点：
  145-146 °C(Press: 9 Torr)
• 密度：
  0.998±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  N,N-二甲基-2-(2-丙氧基乙氧基)乙胺 、 碘甲烷 在 乙醚 作用下， 生成 trimethyl-[2-(2-phenoxy-ethoxy)-ethyl]-ammonium; iodide
  参考文献：
  名称：

  Moszew et al., Zeszyty Naukowe Uniwersytetu Jagiellonskiego., 1955, # 1, p. 189,194

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二甲基乙醇胺钠盐 、 2-苯氧乙基溴 在 甲苯 作用下， 生成 N,N-二甲基-2-(2-丙氧基乙氧基)乙胺
  参考文献：
  名称：

  Moszew et al., Zeszyty Naukowe Uniwersytetu Jagiellonskiego., 1955, # 1, p. 189,193

  摘要：

  DOI：

文献信息

• METHOD FOR PREPARATION OF ARYL POLY(OXALKYL) QUATERNARY AMMONIUM COMPOUND
  申请人：Cheng Che Jim

  公开号：US20140187819A1

  公开（公告）日：2014-07-03

  A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R 1 is H or a C 1 to C 16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R 2 is H or a C 1 to C 16 alkyl group; R 3 is H or a C 1 to C 16 alkyl group; R 4 is a C 1 to C 16 alkyl group; X 1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

  提供一种制备芳基聚（氧烷基）季铵化合物的方法，该方法包括以下步骤：1）在相转移催化剂的作用下，将酚与二卤代聚烯醚反应，得到芳基聚（氧烷基）卤化物；2）在相转移催化剂的作用下，将所述芳基聚（氧烷基）卤化物与胺化试剂反应，得到芳基聚（氧烷基）胺；3）将所述芳基聚（氧烷基）胺与烷基化试剂反应，得到芳基聚（氧烷基）季铵化合物；其中R1为H或C1至C16烷基，位于邻位、间位或对位；n为2至6的整数；R2为H或C1至C16烷基；R3为H或C1至C16烷基；R4为C1至C16烷基；X1为Br或Cl；X为Cl、Br或I。根据本发明的制备方法需要低温低压，反应时间短，总产率可达75%。操作简单，成本低，产品易于分离，具有药品级纯度，有利于大规模生产。
• Nickel Photocatalyzed Reductive 1,4-Dicarbofunctionalization of 1,3-Enynes with <i>N</i>-Methylamines and Organohalides Enabled by Site-Selective C(sp³)–H Functionalization
  作者：Chaozhihui Cheng、Gui-Fen Lv、Shuang Wu、Yang Li、Jin-Heng Li

  DOI：10.1021/acs.orglett.3c01103

  日期：2023.6.16

  catalysis for 1,4-dicarbofunctionalization of 1,3-enynes with tertiary N-methylamines and organohalides to produce tetrasubstituted allenes is presented. This method enables the generation of the aminoalkyl C(sp3)-centered radicals by site selective cleavage of the N-methyl C(sp3)–H bonds in tertiary N-methylamines and is extended to alkyl bromides as the electrophilic terminating regents. Mechanistic

  提出了一种用于 1,3-烯炔与叔N-甲胺和有机卤化物的 1,4-二碳官能化以产生四取代丙二烯的协同镍和光氧化还原还原催化。该方法能够通过对 N-甲基叔胺中的N-甲基C(sp 3 )–H 键进行位点选择性裂解，生成以 C (sp 3 ) 为中心的氨基烷基自由基，并将其扩展为烷基溴作为亲电子终止试剂。机理研究表明该反应涉及自由基过程和Ni 0 /Ni I /Ni III催化循环。
• METHOD FOR PREPARING ARYL POLYOXY ALKYL QUATERNARY AMMONIUM COMPOUND
  申请人：Beijing Sunpu Biochem. Tech. Co., Ltd.

  公开号：EP2703382A1

  公开（公告）日：2014-03-05

  A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R1 is H or a C1 to C16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R2 is H or a C1 to C16 alkyl group; R3 is H or a C1 to C16 alkyl group; R4 is a C1 to C16 alkyl group; X1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

  本发明提供了一种制备芳基聚（氧烷基）季铵化合物的方法，所述方法包括以下步骤：1) 在相转移催化剂的作用下，使苯酚与二卤代聚烷基醚反应，得到芳基聚（氧烷基）卤化物； 2) 在相转移催化剂的作用下，使所述芳基聚（氧烷基）卤化物与胺化试剂反应，得到芳基聚（氧烷基）胺；3) 将所述芳基聚(氧烷基)胺与烷基化试剂反应，得到芳基聚(氧烷基)季铵盐化合物； 其中 R1 是 H 或位于正、偏或对位的 C1 至 C16 烷基；n 是 2 至 6 的整数；R2 是 H 或 C1 至 C16 烷基；R3 是 H 或 C1 至 C16 烷基；R4 是 C1 至 C16 烷基；X1 是 Br 或 Cl；X 是 Cl、Br 或 I。本发明的制备方法需要低温低压，反应时间短，总收率可达 75%。操作简单，成本低，产品易于分离，纯度达到医药级，便于大规模生产。
• Moszew; Inasinski, Roczniki Chemii, 1954, vol. 28, p. 461,464
  作者：Moszew、Inasinski

  DOI：——

  日期：——
• ANIONIC EXCHANGE-HYDROPHOBIC MIXED MODE CHROMATOGRAPHY RESIN
  申请人：BIO-RAD LABORATORIES, INC.

  公开号：US20200406232A1

  公开（公告）日：2020-12-31

  Chromatography resins having anionic exchange-hydrophobic mixed mode ligands, that are useful for purifying target biomolecules using anionic exchange (i.e., where the ligand is positively charged) and hydrophobic mixed mode chromatography. The chromatography resins allow for efficient purification of target biomolecules (e.g., recombinant proteins, antibodies, antibody-drug conjugates, or antibody derivatives including, but not limited to, antibody fragments and antibody fusions) from a sample, and have been found to be useful in purifying monomeric target biomolecules from aggregate target biomolecules. In an embodiment, the chromatography resins are useful for separating antibodies from one or more components (e.g., contaminants) in the sample.