N-(2-Azido-ethyl)-2-nitro-benzenesulfonamide | 848356-36-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-Azido-ethyl)-2-nitro-benzenesulfonamide
• 英文别名: N-(2-azidoethyl)-2-nitrobenzenesulfonamide
• CAS: 848356-36-5
• 化学式: C₈H₉N₅O₄S
• 分子量: 271.257
• InChiKey: KPKVIZXNOUTZFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-(2-Azido-ethyl)-2-nitro-benzenesulfonamide 在 18-冠醚-6 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 96.0h， 生成 [6-Methyl-4-(2-nitro-benzenesulfonyl)-3,4-dihydro-2H-pyrazin-1-yl]-phenyl-methanone
  参考文献：
  名称：

  Intramolecular [2+3]-addition of an azide to a CC double bond as a novel approach to piperazines

  摘要：

  An intramolecular [2+3]-cycloaddition of an azide to a C=C double bond was carried out to obtain hexahydro[1,2,3]triazolo[1,5-a]pyrazines. These compounds were used as intermediates to prepare 2-(halogenomethyl)piperazines that could serve as precursors for various condensed derivatives. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.12.071
• 作为产物：
  描述：

  N-(2-羟基乙基)-2-硝基苯磺酰胺 在 sodium azide 、 TEA 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-(2-Azido-ethyl)-2-nitro-benzenesulfonamide
  参考文献：
  名称：

  Intramolecular [2+3]-addition of an azide to a CC double bond as a novel approach to piperazines

  摘要：

  An intramolecular [2+3]-cycloaddition of an azide to a C=C double bond was carried out to obtain hexahydro[1,2,3]triazolo[1,5-a]pyrazines. These compounds were used as intermediates to prepare 2-(halogenomethyl)piperazines that could serve as precursors for various condensed derivatives. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.12.071

文献信息

• Intramolecular [2+3]-addition of an azide to a CC double bond as a novel approach to piperazines
  作者：Tatjana V. Lukina、Sergey I. Sviridov、Sergey V. Shorshnev、Grigory G. Alexandrov、Aleksandr E. Stepanov

  DOI：10.1016/j.tetlet.2004.12.071

  日期：2005.2

  An intramolecular [2+3]-cycloaddition of an azide to a C=C double bond was carried out to obtain hexahydro[1,2,3]triazolo[1,5-a]pyrazines. These compounds were used as intermediates to prepare 2-(halogenomethyl)piperazines that could serve as precursors for various condensed derivatives. (C) 2004 Elsevier Ltd. All rights reserved.