3a,4-Dihydro-3H-isobenzofuran-1-one | 6711-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异苯并呋喃
• 英文名称: 3a,4-Dihydro-3H-isobenzofuran-1-one
• 英文别名: 3a,4-dihydro-3H-2-benzofuran-1-one
• CAS: 6711-40-6
• 化学式: C₈H₈O₂
• 分子量: 136.15
• InChiKey: YSZZIRWBOXXOIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3a,4-Dihydro-3H-isobenzofuran-1-one 、 N-苯基马来酰亚胺 以58%的产率得到
  参考文献：
  名称：

  NOGUCHI, MICHIHIKO;KAKIMOTO, SHINJI;KAJIGAESHI, SHOJI, CHEM. LETT., 1985, N 2, 151-154

  摘要：

  DOI：
• 作为产物：
  描述：

  allyl 2-pyrone-6-carboxylate 生成 3a,4-Dihydro-3H-isobenzofuran-1-one
  参考文献：
  名称：

  NOGUCHI, MICHIHIKO;KAKIMOTO, SHINJI;KAJIGAESHI, SHOJI, CHEM. LETT., 1985, N 2, 151-154

  摘要：

  DOI：

文献信息

• [EN] USE OF UREA VARIANTS AS AFFINITY LIGANDS<br/>[FR] UTILISATION DE VARIANTES D'UREES EN TANT QUE LIGANDS A AFFINITE
  申请人：AMERSHAM BIOSCIENCES AB

  公开号：WO2004039765A1

  公开（公告）日：2004-05-13

  The present invention relates to an IgG-binding compound, which more specifically has affinity for human IgGs of k-type and functional derivatives thereof. More specifically, the compound according to the invention comprises an N,N-alkylated urea moiety located between an aromatic part and another part, which is a linear or cyclic substituted or unsubstituted aliphatic group. The compound binds to a pocket-shaped binding site present on all human IgG k-Fabs, which site is located between the two domains (CH1 and CL) of its constant part. Accordingly, the compound according to the invention is a ligand for human IgGs of k-type, and consequently, the invention also relates to a separation matrix for affinity chromatography, which matrix comprises said compound, as well as to other uses of the compound.

  本发明涉及一种IgG结合化合物，更具体地具有对人类k型IgG及其功能衍生物的亲和力。具体而言，本发明的化合物包括位于芳香部分和另一部分之间的N，N-烷基化脲基团，该另一部分是线性或环状取代或未取代的脂肪族基团。该化合物结合到所有人类IgG k-Fab中存在的口袋状结合位点，该位点位于其常数部分的两个域（CH1和CL）之间。因此，本发明的化合物是人类k型IgG的配体，因此，本发明还涉及一种亲和层析的分离基质，该基质包括所述化合物，以及化合物的其他用途。
• STEREOSELECTIVE SYNTHESIS OF 3a,4,5,7a-TETRAHYDRO-5,7a-ETHANOPHTHALIDE DERIVATIVES USING SUCCESSIVE INTRA- AND INTERMOLECULAR DIELS–ALDER REACTIONS
  作者：Michihiko Noguchi、Shinji Kakimoto、Shoji Kajigaeshi

  DOI：10.1246/cl.1985.151

  日期：1985.2.5

  moieties underwent the intramolecular Diels–Alder reaction followed by the extrusion of carbon dioxide to give 3a, 4-dihydrophthalide derivatives. The dihydrophthalides added to the second dienophiles intermolecularly to give 3a,4,5,7a-tetrahydro-5,7a-ethanophthalide derivatives. The stereoselectivity of the 5,7a-ethanophthalides was liable for the two successive reactions.

  一些在酯部分带有适当亲二烯体的 2-pyrone-6-羧酸酯经历了分子内 Diels-Alder 反应，然后挤出二氧化碳得到 3a, 4-dihydrophthalide 衍生物。将二氢邻苯二甲醚分子间加到第二个亲二烯体中，得到 3a,4,5,7a-四氢-5,7a-乙苯酞衍生物。5,7a-乙酰苯酞的立体选择性有利于两个连续反应。
• Use of urea variants as affinity ligands
  申请人：Axen Andreas

  公开号：US20060014735A1

  公开（公告）日：2006-01-19

  The present invention relates to an IgG-binding compound, which more specifically has affinity for human IgGs of κ-type and functional derivatives thereof. More specifically, the compound according to the invention comprises an N,N-alkylated urea moiety located between an aromatic part and another part, which is a linear or cyclic substituted or unsubstituted aliphatic group. The compound binds to a pocket-shaped binding site present on all human IgG κ-Fabs, which site is located between the two domains (CH1 and CL) of its constant part. Accordingly, the compound according to the invention is a ligand for human IgGs of κ-type, and consequently, the invention also relates to a separation matrix for affinity chromatography, which matrix comprises said compound, as well as to other uses of the compound.

  本发明涉及一种IgG结合化合物，更具体地具有对人类κ型IgG及其功能衍生物的亲和力。更具体地，根据本发明，该化合物包括位于芳香部分和另一部分之间的N,N-烷基化脲基团，该另一部分是线性或环状取代或未取代的脂肪族基团。该化合物结合到所有人类IgG κ-Fab上存在的口袋状结合位点，该位点位于其恒定部分的两个域（CH1和CL）之间。因此，根据本发明，该化合物是人类κ型IgG的配体，因此，本发明还涉及一种亲和层析的分离基质，该基质包括所述化合物，以及该化合物的其他用途。
• Reaction of 3a,4-Dihydrophthalides with Acetylenic Dienophiles
  作者：Michihiko Noguchi、Shinji Kakimoto、Shoji Kajigaeshi

  DOI：10.3987/r-1986-03-0665

  日期：——
• NOGUCHI MICHIHIKO; KAKIMOTO SHINJI; KAJIGAESHI SHOJI, HETEROCYCLES, 24,(1986) N 4, 665-668
  作者：NOGUCHI MICHIHIKO、 KAKIMOTO SHINJI、 KAJIGAESHI SHOJI

  DOI：——

  日期：——