N,N-二甲基-N,N-二亚硝基-p-苯二胺 | 6947-38-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N,N-二甲基-N,N-二亚硝基-p-苯二胺
• 中文别名: N,N'-二甲基-N,N'-二硝基-P-苯肼
• 英文名称: N,N'-dimethyl-N,N'-dinitroso-p-phenylenediamine
• 英文别名: N,N'-(1,4-phenylene)bis(N-methylnitrous amide)；N,N'-dimethyl-N,N'-dinitroso-p-phenylenediamine；N,N'-Dimethyl-N,N'-dinitroso-p-phenylendiamin；p-Phenylen-bis-(methyl-nitrosamin)；N-methyl-N-[4-[methyl(nitroso)amino]phenyl]nitrous amide
• CAS: 6947-38-2
• 化学式: C₈H₁₀N₄O₂
• mdl: MFCD02683316
• 分子量: 194.193
• InChiKey: WKDYJAMEXVFEEA-UHFFFAOYSA-N

物化性质

• 熔点：
  120-121°C
• 溶解度：
  溶于氯仿，

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N,N-二甲基-N,N-二亚硝基-p-苯二胺 在 cobalt(II) 5,10,15,20-tetraphenylporphyrin 作用下， 以 苯 为溶剂， 生成 N,N'-Dimethyl-1,4-benzochinondiimin
  参考文献：
  名称：

  High-Performance Caged Nitric Oxide:  A New Molecular Design, Synthesis, and Photochemical Reaction

  摘要：

  DOI：

  10.1021/ja962839d
• 作为产物：
  描述：

  N,N,N',N'-四甲基对苯二胺 在 亚硝酸特丁酯 、 2,2,6,6-四甲基哌啶氧化物 作用下， 以 乙腈 为溶剂， 反应 6.5h， 以66%的产率得到N,N-二甲基-N,N-二亚硝基-p-苯二胺
  参考文献：
  名称：

  空间和热力学因素调节的高选择性sp 3 C–N键活化叔苯胺

  摘要：

  使用TBN / TEMPO催化剂系统可实现对叔苯胺的高选择性sp 3 C–N裂解。当使用N，N-二烯丙基苯胺（烷基，苄基）时，N–CH 3键通过C–H自由基活化被选择性裂解。此外，当安装烯丙基时，观察到完全相反的选择性。值得注意的是，溶剂效应对于获得高反应效率和选择性也至关重要。

  DOI：

  10.1039/c7gc02775c

文献信息

• Isoxazole group directed Rh(iii)-catalyzed alkynylation using TIPS-EBX
  作者：Sukanya Das、Tanmoy Datta、Md. Abbasuddin Sk、Brindaban Roy、Raj K. Nandi

  DOI：10.1039/d4ob00797b

  日期：——

  A highly effective isoxazole directed ortho C–H alkynylation has been developed. Rhodium(III) catalyzed direct di-(and/or mono) alkynylation using a hypervalent iodine reagent (TIPS-EBX) is reported. The reaction proceeds with a wide substrate scope under benign conditions. Preliminary mechanistic studies support this chelation assisted C–H alkynylation.

  一种高效的异恶唑定向邻位C-H 炔基化反应已被开发出来。据报道，使用高价碘试剂 (TIPS-EBX) 进行铑 ( III ) 催化的直接二（和/或单）炔基化。该反应在良好的条件下以广泛的底物范围进行。初步机制研究支持这种螯合辅助的 C-H 炔基化。
• Bis- N -nitroso-caged nitric oxides: photochemistry and biological performance test by rat aorta vasorelaxation
  作者：Shigeyuki Namiki、Fusako Kaneda、Masashi Ikegami、Tatsuo Arai、Ken Fujimori、Sachie Asada、Hiroshi Hama、Yoshitoshi Kasuya、Katsutoshi Goto

  DOI：10.1016/s0968-0896(99)00084-x

  日期：1999.8

  Three new caged nitric oxides (NOs)-BNN3, BNN5Na, and BNN5M-were tested for biological use. BNNs have a strong ultraviolet (UV) absorption band (lambda(max): 300 nm, epsilon: 13.5 mM(-1) cm(-1)) extended to 420 nm and produce NO upon irradiation with 300-360 nm light in quantum yields about 2. A photoexcited BNN molecule yields two NOs with time constants of less than 10 ns for phase 1 and less than 20 mu s for phase 2 at 37 degrees C, suggesting usefulness of BNNs for measuring in vivo and in vitro fast NO reactions. Upon irradiating with UV light, caged nitric oxides-loaded rat aortic strips maintained in a state of active tonic contraction effectively relaxed (<3 mu M BNN5M loading solution concentration). BNN3 is incorporated in the lipid membrane. BNN5Na, insoluble in organic solvents but water soluble, localizes in the water phase. BNN5M, is muscle-cell-permeable and hydrolysed to BNN5Na to remain in cytosol. BNNs were thermally stable and demonstrated no observable toxicity. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Methods and compositions for regulating biofilm development
  申请人：NewSouth Innovations Pty Limited

  公开号：EP2351828B1

  公开（公告）日：2017-10-18
• A GNRH ANTAGONIST FOR USE IN THE TREATMENT OF A WOMEN AFFECTED WITH POLYCYSTIC OVARY SYNDROME
  申请人：Institut National de la Santé et de la Recherche Médicale

  公开号：EP3600373A1

  公开（公告）日：2020-02-05
• METHOD AND DEVICE FOR TREATING BURSITIS
  申请人：Jacques Danniel

  公开号：US20080254107A1

  公开（公告）日：2008-10-16

  The present invention relates to a method for treating a subject for a condition or inflammation associated with oedema, excess body fluids or oedema and excess body fluids, or for treating a subject for an abscess, boil, blister or cyst. The method comprises applying to the skin surface covering a body part or region affected by said condition, inflammation, abscess, boil, blister or cyst a composition capable of transdermally attracting fluids from the body part or region or its proximity, wherein said composition comprises at least one adsorptive or absorptive agent, and leaving said composition in contact with the skin for sufficient time to allow said composition to transdermally absorb or adsorb at least a portion of the body fluids from said body part or region. The present invention also relates to compositions for absorbing or adsorbing fluids from a body part or region, and which are capable of transdermally attracting fluids from body parts or regions or their proximity.