N,N-二甲基十三烷胺 | 17373-29-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N-二甲基十三烷胺
• 中文别名: 十三叔胺；1-(二甲氨基)十三烷；1-(二甲基氨基)十三烷
• 英文名称: 1-(dimethylamino)tridecane
• 英文别名: N,N-dimethyl tridecylamine；N,N-dimethyltridecylamine；N,N-dimethyldodecylamine；di-(methyl)tridecylamine；tridecyl-dimethylamine；dimethyltridecylamine；N,N-dimethyltridecan-1-amine
• CAS: 17373-29-4
• 化学式: C₁₅H₃₃N
• mdl: MFCD00077747
• 分子量: 227.434
• InChiKey: ADXNPXDFKKWVGE-UHFFFAOYSA-N

物化性质

• 熔点：
  -61.15°C (estimate)
• 沸点：
  64-65 °C/0.15 mmHg (lit.)
• 密度：
  0.792 g/mL at 20 °C (lit.)
• 闪点：
  109℃

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S23,S24/25
• 危险类别码：
  R38
• 海关编码：
  2921199090
• WGK Germany：
  2

反应信息

• 作为反应物：
  描述：

  1,5-二溴戊烷 、 N,N-二甲基十三烷胺 以 异丙醇 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Antibacterial Activity, in Vitro Cytotoxicity, and Cell Cycle Arrest of Gemini Quaternary Ammonium Surfactants

  摘要：

  Twelve gemini quaternary ammonium surfactants have been employed to evaluate the antibacterial activity and in vitro cytotoxicity. The antibacterial effects of the gemini surfactants are performed on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) with minimum inhibitory concentrations (MIC) ranging from 2.8 to 167.7 mu M. Scanning electron microscopy (SEM) analysis results show that these surfactants interact with the bacterial cell membrane, disrupt the integrity of the membrane, and consequently kill the bacteria. The data recorded on C6 glioma and HEK293 human kidney cell lines using an MTT assay exhibit low half inhibitory concentrations (IC50). The influences of the gemini surfactants on the cell morphology, the cell migration ability, and the cell cycle are observed through hematoxylin-eosin (HE) staining, cell wound healing assay, and flow cytometric analyses, respectively. Both the values of MIC and IC50 decrease against the growth of the alkyl chain length of the gemini surfactants with the same spacer group. In the case of surfactants 12-s-12, the MICs and IC(50)s are found to decrease slightly with the spacer chain length changing from 2 to 8 and again to increase at higher spacer length (s = 10-12). All of the gemini surfactants show great antibacterial activity and cytotoxicity, and they might exhibit potential applications in medical fields.

  DOI：

  10.1021/acs.langmuir.5b01430
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 palladium on activated charcoal 氢气 作用下， 25.0 ℃ 、303.97 kPa 条件下， 生成 N,N-二甲基十三烷胺
  参考文献：
  名称：

  Competing hydride transfer and ene reactions in the aminoalkylation of 1-alkenes with N,N-dimethylmethyleniminium ions. A literature correction

  摘要：

  DOI：

  10.1021/jo00172a018

文献信息

• [EN] SOLVENTS<br/>[FR] SOLVANTS
  申请人：BIONIQS LTD

  公开号：WO2009034329A1

  公开（公告）日：2009-03-19

  There is described the use of a protic ionic liquid comprising a trialkylammonium salt as a solvent.

  这里描述了一种包含三烷基铵盐的质子离子液体作为溶剂的使用。
• N-Methylation of amines and nitroarenes with methanol using heterogeneous platinum catalysts
  作者：Md.A.R. Jamil、Abeda S. Touchy、Md. Nurnobi Rashed、Kah Wei Ting、S.M.A. Hakim Siddiki、Takashi Toyao、Zen Maeno、Ken-ichi Shimizu

  DOI：10.1016/j.jcat.2019.01.027

  日期：2019.3

  We report herein the selective N-methylation of amines and nitroarenes with methanol under basic conditions using carbon-supported Pt nanoparticles (Pt/C) as a heterogeneous catalyst. This method is widely applicable to four types of N-methylation reactions: (1) N,N-dimethylation of aliphatic amines under N2, (2) N-monomethylation of aliphatic amines under 40 bar H2, (3) N-monomethylation of aromatic

  我们在此报告了在碱性条件下使用碳载Pt纳米颗粒（Pt / C）作为非均相催化剂，用甲醇对胺和硝基芳烃进行选择性N-甲基化的过程。该方法广泛适用于四种类型的Ñ -methylation反应：（1）N，N-氮气氛下脂族胺的-dimethylation 2，（2）Ñ -monomethylation下40巴脂族胺为h 2，（3）ñ -monomethylation N 2下的芳香胺的合成；（4）在2 bar H 2下由硝基芳烃和甲醇串联合成N-甲基苯胺。在相同的催化系统下，所有这些反应均显示出适用于多种底物的相应甲胺的收率高，周转率高（TON）和良好的催化剂可重复使用性。机理研究表明，反应是通过借用氢的方法进行的。动力学结果结合密度泛函理论（DFT）计算表明，Pt / C的高性能归因于Pt中等的金属-氢键强度。
• LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
  申请人：Acuitas Therapeutics, Inc.

  公开号：US20160376224A1

  公开（公告）日：2016-12-29

  Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1a , R 1b , R 2a , R 2b, R 3a , R 3b , R 4a , R 4b , R 5 , R 6 , R 7 , R 8 , R 9 , L 1 , L 2 , G 1 , G 2 , G 3 , a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

  提供具有以下结构的化合物：或其药用可接受的盐、互变异构体或立体异构体，其中R1a、R1b、R2a、R2b、R3a、R3b、R4a、R4b、R5、R6、R7、R8、R9、L1、L2、G1、G2、G3、a、b、c和d如本文所定义。还提供了将这些化合物用作脂质纳米粒子配方的组分以传递治疗剂、包含这些化合物的组合物以及其使用和制备方法。
• QUATERNARY AMMONIUM SALT-CONTAINING CATALYST FOR DISSOCIATION OF BLOCKING AGENT AND USE THEREOF
  申请人：TOSOH CORPORATION

  公开号：US20150344727A1

  公开（公告）日：2015-12-03

  A catalyst containing a quaternary ammonium salt represented by the following general formula (1) is used as a catalyst for dissociation of a blocking agent. [In the formula, each of R 1 to R 3 represents an aliphatic hydrocarbon group having 1 to 8 carbon atoms or an aromatic hydrocarbon group having 6 to 14 carbon atoms; R 4 represents an aliphatic hydrocarbon group having 9 to 20 carbon atoms; X represents at least one member selected from the group consisting of a phosphate group, a borate group, a hydrogencarbonate group, a monoalkylcarbonate group and a carbonate group; a is an integer in the range of 1 to 3; and b is an integer in the range of 1 to 3.]

  一种催化剂包含一个由以下通用公式（1）表示的季铵盐，用作分解阻塞剂的催化剂。【在公式中，R1至R3中的每一个代表具有1至8个碳原子的脂肪烃基或具有6至14个碳原子的芳香烃基；R4代表具有9至20个碳原子的脂肪烃基；X代表选择自磷酸盐、硼酸盐、碳酸氢盐、单烷基碳酸盐和碳酸盐组成的至少一种成员；a是在1到3范围内的整数；b是在1到3范围内的整数。】
• Recycling of homogeneous catalysts in reactive ionic liquid – solvent-free aminofunctionalizations of alkenes
  作者：Thiemo A. Faßbach、Robin Kirchmann、Arno Behr、Andreas J. Vorholt

  DOI：10.1039/c7gc02272g

  日期：——

  out in neat substrates without additional solvents. The ionic character of dimcarb enables the immobilization of the active catalysts in the reactive ionic liquid, using sulfonated ligands. Investigations regarding the hydroamination of 1,3-dienes led to a total turnover number (TTON) of more than 8,700 with β-farnesene in 12 repetitive recycling experiments. The telomerization of 1,3-butadiene was carried

  均相催化的氨基官能化中的催化剂通常难以再循环，使得这些反应在工业规模上昂贵。使用二甲基氨基甲酸酯二甲铵（dimcarb）作为反应性离子液体为应对这一挑战提供了一种完美的解决方案，因为它同时是基质和极性相。在这项工作中，均质过渡金属催化的反应-特别是加氢胺化，端粒化和氢氨基甲基化-在纯净的底物中进行，无需其他溶剂。Dimcarb的离子特性使得可以使用磺化的配体将活性催化剂固定在反应性离子液体中。在12个重复循环实验中，有关1,3-二烯加氢胺化的研究导致β-法呢烯的总周转率（TTON）超过8,700。