N-(Butan-2-YL)-5-(3-methoxyphenyl)-1,2-oxazole-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(Butan-2-YL)-5-(3-methoxyphenyl)-1,2-oxazole-3-carboxamide
• 英文别名: N-butan-2-yl-5-(3-methoxyphenyl)-1,2-oxazole-3-carboxamide
• 化学式: C₁₅H₁₈N₂O₃
• 分子量: 274.31
• InChiKey: IUMLXTKGMWZGHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ISOXAZOLE TREATMENTS FOR FRONTOTEMPORAL DEMENTIA
  申请人：The Board of Regents of the University of Texas System

  公开号：US20170172987A1

  公开（公告）日：2017-06-22

  The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of frontotemporal dementia.
• [EN] ISOXAZOLE TREATMENTS FOR FRONTOTEMPORAL DEMENTIA<br/>[FR] TRAITEMENTS À BASE D'ISOXAZOLE POUR LA DÉMENCE FRONTO-TEMPORALE
  申请人：UNIV TEXAS

  公开号：WO2015143300A1

  公开（公告）日：2015-09-24

  The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of frontotemporal dementia.