dimethyl 2-(4-(4-methoxyphenyl)buta-2,3-dienyl)malonate | 1206604-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: dimethyl 2-(4-(4-methoxyphenyl)buta-2,3-dienyl)malonate
• CAS: 1206604-37-6
• 化学式: C₁₆H₁₈O₅
• 分子量: 290.316
• InChiKey: XBKPPVKMLFCOJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  dimethyl 2-ethynylcyclopropane-1,1-dicarboxylate 、 4-甲氧基苯基溴化镁 在 copper(l) cyanide 作用下， 以 乙醚 为溶剂， 以79%的产率得到dimethyl 2-(4-(4-methoxyphenyl)buta-2,3-dienyl)malonate
  参考文献：
  名称：

  Synthesis of Enantioenriched Allenes from 1,1-Cyclopropanediesters

  摘要：

  Highly substituted allenes were obtained by the S(N)2' addition of organocuprate reagents on 2-propargyl-1,1-cyclopropanediesters. This new methodology permits the synthesis of highly enantioenriched allenes as the reaction proceeds with retention of the enantiomeric purity of the starting cyclopropane. The use of higher order cuprates was instrumental in obtaining the reported results.

  DOI：

  10.1021/ol902766f

文献信息

• Synthesis of Enantioenriched Allenes from 1,1-Cyclopropanediesters
  作者：Pascal Cérat、Philipp J. Gritsch、Sébastien R. Goudreau、André B. Charette

  DOI：10.1021/ol902766f

  日期：2010.2.5

  Highly substituted allenes were obtained by the S(N)2' addition of organocuprate reagents on 2-propargyl-1,1-cyclopropanediesters. This new methodology permits the synthesis of highly enantioenriched allenes as the reaction proceeds with retention of the enantiomeric purity of the starting cyclopropane. The use of higher order cuprates was instrumental in obtaining the reported results.