7,9-bis-[1-(2,4-dichloro-phenyl)-meth-(E)-ylidene]-1,4-dioxa-spiro[4,5]-decan-8-one | 1219496-82-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 7,9-bis-[1-(2,4-dichloro-phenyl)-meth-(E)-ylidene]-1,4-dioxa-spiro[4,5]-decan-8-one
• 英文别名: (7E,9E)-7,9-bis[(2,4-dichlorophenyl)methylidene]-1,4-dioxaspiro[4.5]decan-8-one
• CAS: 1219496-82-8
• 化学式: C₂₂H₁₆Cl₄O₃
• 分子量: 470.179
• InChiKey: VDQCFSKXUIUXKJ-BGPOSVGRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,4-环己二酮单乙二醇缩酮 、 2,4-二氯苯甲醛 在 potassium carbonate 作用下， 以 水 为溶剂， 反应 0.13h， 以95%的产率得到7,9-bis-[1-(2,4-dichloro-phenyl)-meth-(E)-ylidene]-1,4-dioxa-spiro[4,5]-decan-8-one
  参考文献：
  名称：

  Green, Microwave-Assisted Approach to the Synthesis of Arylidene-Substituted Spiro[4,5]decan-8-one Derivatives in Water

  摘要：

  A green approach to the synthesis of arylidene-substituted spiro[4,5]decan-8-one derivatives was successfully realized via the mild, base-catalyzed reaction of aromatic aldehydes with 1,4-dioxa-spiro[4.5]decan-8-one in water under microwave irradiation. This protocol has the prominent advantages of environmental friendliness, short reaction time, excellent yields, low cost, easy operation, and broad scope of applicability.

  DOI：

  10.1080/00397910903009471

文献信息

• Green, Microwave-Assisted Approach to the Synthesis of Arylidene-Substituted Spiro[4,5]decan-8-one Derivatives in Water
  作者：Ju-Hua Peng、Xiao-Hong Zhang、Feng Shi、Wen-Juan Hao、Shu-Jiang Tu

  DOI：10.1080/00397910903009471

  日期：2010.2.2

  A green approach to the synthesis of arylidene-substituted spiro[4,5]decan-8-one derivatives was successfully realized via the mild, base-catalyzed reaction of aromatic aldehydes with 1,4-dioxa-spiro[4.5]decan-8-one in water under microwave irradiation. This protocol has the prominent advantages of environmental friendliness, short reaction time, excellent yields, low cost, easy operation, and broad scope of applicability.