1,5-Dimethyl-1H-pyrrole-2-carboxylic acid [1-(2-chloro-phenyl)-eth-(E)-ylidene]-hydrazide | 133662-14-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,5-Dimethyl-1H-pyrrole-2-carboxylic acid [1-(2-chloro-phenyl)-eth-(E)-ylidene]-hydrazide
• 英文别名: N-[(E)-1-(2-chlorophenyl)ethylideneamino]-1,5-dimethylpyrrole-2-carboxamide
• CAS: 133662-14-3
• 化学式: C₁₅H₁₆ClN₃O
• 分子量: 289.765
• InChiKey: VLFGAFRBUKDEGS-GZTJUZNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻氯苯乙酮 、 1,5-二甲基-1H-吡咯-2-甲酰肼 以 乙醇 为溶剂， 反应 3.0h， 生成 1,5-Dimethyl-1H-pyrrole-2-carboxylic acid [1-(2-chloro-phenyl)-eth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  Antihypertensive hydrazidones: α-aminoacylated 2-chlorobenzylidene hydrazines

  摘要：

  Hydrazides of amino acids and acylamino acids were condensed with 2-chlorobenzaldehyde or 2-chloroacetophenone. The hydrazidones obtained exhibited antihypertensive activity. In a few cases the activities were similar or higher than those of the reference compounds.

  DOI：

  10.1016/0223-5234(94)90064-7

文献信息

• GALONS, H.;CAVE, C.;MIOCQUE, M.;RINJARD, P.;TRAN, G.;BINET, P., EUR. J. MED. CHEM., 25,(1990) N, C. 785-788
  作者：GALONS, H.、CAVE, C.、MIOCQUE, M.、RINJARD, P.、TRAN, G.、BINET, P.

  DOI：——

  日期：——
• Antihypertensive hydrazidones: α-aminoacylated 2-chlorobenzylidene hydrazines
  作者：C Cavé、H Galons、M Miocque、P Rinjard、G Tran、P Binet

  DOI：10.1016/0223-5234(94)90064-7

  日期：1994.1

  Hydrazides of amino acids and acylamino acids were condensed with 2-chlorobenzaldehyde or 2-chloroacetophenone. The hydrazidones obtained exhibited antihypertensive activity. In a few cases the activities were similar or higher than those of the reference compounds.