4-(4-chloro-2-methylphenoxy)-N-(5-methyl-1,3-thiazol-2-yl)butanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(4-chloro-2-methylphenoxy)-N-(5-methyl-1,3-thiazol-2-yl)butanamide
• 化学式: C₁₅H₁₇ClN₂O₂S
• 分子量: 324.8
• InChiKey: YPGYAGPTEYOGEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ACTIVATORS OF HIV LATENCY
  申请人：The Walter and Eliza Hall Institute of Medical Research

  公开号：US20190330167A1

  公开（公告）日：2019-10-31

  The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating HIV expression in latently infected cells. Further still, the invention relates to pharmaceutical compositions comprising the novel compounds in combination with anti-HIV therapy compounds and their use in treating HIV infection in both animals and humans. The invention further provides means for preparing the compounds.