[(E)-6-[[2-[benzoyl(butyl)amino]-3-methylbutanoyl]amino]hex-2-enyl] methyl carbonate | 1008751-47-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(E)-6-[[2-[benzoyl(butyl)amino]-3-methylbutanoyl]amino]hex-2-enyl] methyl carbonate
• CAS: 1008751-47-0
• 化学式: C₂₄H₃₆N₂O₅
• 分子量: 432.56
• InChiKey: WHPKWLUJLYPCPK-MDWZMJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-isocyanohex-2-enyl methyl carbonate 、 正丁胺 、 异丁醛 、 苯甲酸 在 4 A molecular sieve 作用下， 以 乙醇 、 2,2,2-三氟乙醇 为溶剂， 生成 、 [(E)-6-[[2-[benzoyl(butyl)amino]-3-methylbutanoyl]amino]hex-2-enyl] methyl carbonate
  参考文献：
  名称：

  Polyfunctionalized Pyrrolidines by Ugi Multicomponent Reaction Followed by Palladium-Mediated S_N2‘ Cyclizations

  摘要：

  [GRAPHICS]A 4-component Ugi reaction with a suitable isocyanide, followed by a novel secondary transformation involving a Pd(II)-mediated (R-5 = H) or a Pd(0)-mediated (RI = CO2Me) S(N)2' cyclization to give highly functionalized N-acyl-2-vinylpyrrolidines, is reported. The overall yields are usually good and in most cases the Pd(0)-catalyzed reaction gave the final product in almost quantitative yield.

  DOI：

  10.1021/jo702087x

文献信息

• Polyfunctionalized Pyrrolidines by Ugi Multicomponent Reaction Followed by Palladium-Mediated S_N2‘ Cyclizations
  作者：Luca Banfi、Andrea Basso、Valentina Cerulli、Giuseppe Guanti、Renata Riva

  DOI：10.1021/jo702087x

  日期：2008.2.1

  [GRAPHICS]A 4-component Ugi reaction with a suitable isocyanide, followed by a novel secondary transformation involving a Pd(II)-mediated (R-5 = H) or a Pd(0)-mediated (RI = CO2Me) S(N)2' cyclization to give highly functionalized N-acyl-2-vinylpyrrolidines, is reported. The overall yields are usually good and in most cases the Pd(0)-catalyzed reaction gave the final product in almost quantitative yield.