4,4'-(perfluoropropane-2,2-diyl)bis(2,6-dibromophenol) | 5281-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-(perfluoropropane-2,2-diyl)bis(2,6-dibromophenol)
• 英文别名: 2,6-dibromo-4-[2-(3,5-dibromo-4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-yl]phenol
• CAS: 5281-28-7
• 化学式: C₁₅H₆Br₄F₆O₂
• 分子量: 651.818
• InChiKey: BDCSAEPSPIEGAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4,4'-(perfluoropropane-2,2-diyl)bis(2,6-dibromophenol) 、 环氧氯丙烷 在 四丁基溴化铵 、 potassium hydroxide 作用下， 反应 12.0h， 以95%的产率得到2,2'-(4,4'-(perfluoropropane-2,2-diyl)bis(2,6-dibromo-4,1-phenylene))bis(oxy)bis(methylene)dioxirane
  参考文献：
  名称：

  Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors

  摘要：

  The aggregation of A beta is a crucial step in the etiology of Alzheimer's disease. Our previous work showed that A beta undergoes alpha-helix/beta-sheet intermediate structures during the conformational transition, and an A beta aggregation inhibitor (1) was discovered by targeting the intermediates. Here, structure optimization toward compound 1 was performed and 34 novel derivatives were designed and synthesized. Nine compounds showed more effective inhibitory activity than the hit compound 1 in ThT fluorescence assay. Among them, compound 43 demonstrated more excellent inhibitory potency, which not only can suppress the aggregation of A beta but also can dissolve the preformed fibrils as shown by CD spectroscopy, PICUP and AFM assays. Cellular assay indicated that 43 has no toxicity to neuronal cells, moreover, can effectively inhibit A beta(1-42)-induced neutrotoxicity and increase the cell viability. Together, on the basis of these positive results, these novel chemical structures may provide a promising potential for therapeutic applications in AD and other types of neurodegenerative disorders.

  DOI：

  10.1021/jm1000584
• 作为产物：
  描述：

  六氟双酚 A 在 溴 、 溶剂黄146 作用下， 以92%的产率得到4,4'-(perfluoropropane-2,2-diyl)bis(2,6-dibromophenol)
  参考文献：
  名称：

  Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors

  摘要：

  The aggregation of A beta is a crucial step in the etiology of Alzheimer's disease. Our previous work showed that A beta undergoes alpha-helix/beta-sheet intermediate structures during the conformational transition, and an A beta aggregation inhibitor (1) was discovered by targeting the intermediates. Here, structure optimization toward compound 1 was performed and 34 novel derivatives were designed and synthesized. Nine compounds showed more effective inhibitory activity than the hit compound 1 in ThT fluorescence assay. Among them, compound 43 demonstrated more excellent inhibitory potency, which not only can suppress the aggregation of A beta but also can dissolve the preformed fibrils as shown by CD spectroscopy, PICUP and AFM assays. Cellular assay indicated that 43 has no toxicity to neuronal cells, moreover, can effectively inhibit A beta(1-42)-induced neutrotoxicity and increase the cell viability. Together, on the basis of these positive results, these novel chemical structures may provide a promising potential for therapeutic applications in AD and other types of neurodegenerative disorders.

  DOI：

  10.1021/jm1000584

文献信息

• Tetrabromo bisphenol based polyestercarbonate membranes and method of using
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0244126A2

  公开（公告）日：1987-11-04

  The invention is a membrane comprising a dense skin of a polyestercarbonate, wherein the diphenolic residue in the backbone of the polyestercarbonate is a tetrabromo diphenolic residue, wherein the membrane has a separation factor for oxygen and nitrogen of 6.5 or greater at 24°C. In another aspect, the invention is a method of separating oxygen from a mixture of gases comprising nitrogen and oxygen, wherein the method comprises (a) contacting the gas mixture with one side of a thin, non-porous membrane comprising a polyestercarbonate described hereinbefore while maintaining a pressure difference across the membrane with the lower pressure being on the other side of the membrane; and (b) removing the permeated oxygen from the other side of the membrane, wherein separation factor for the oxygen and nitrogen is 6.5 or greater at 24°C. The membranes of this invention demonstrate surprisingly high separation factors for oxygen and nitrogen separations. The membranes of this invention have good mechanical properties and therefore are useful under more extreme conditions, for example temperature and pressure, than many commercially used membranes.

  本发明是一种由聚酯碳酸酯致密表皮组成的膜，其中聚酯碳酸酯骨架中的二酚残基为四溴二酚残基，在 24°C 时，膜的氧氮分离系数为 6.5 或更大。在另一个方面，本发明是一种从包括氮气和氧气的气体混合物中分离氧气的方法，其中该方法包括：(a) 将气体混合物与包括前述聚酯碳酸酯的无孔薄膜的一侧接触，同时保持膜两侧的压力差，较低的压力位于膜的另一侧；(b) 从膜的另一侧除去渗透的氧气，其中氧气和氮气的分离系数在 24°C 时为 6.5 或更大。本发明的膜在氧气和氮气分离方面表现出令人惊讶的高分离系数。本发明的膜具有良好的机械性能，因此与许多商业使用的膜相比，可以在更极端的条件下使用，例如温度和压力。
• Semipermeable membranes based on specified tetrabromobisphenol type polyesters
  申请人：PRAXAIR TECHNOLOGY, INC.

  公开号：EP0376234A2

  公开（公告）日：1990-07-04

  Permeable membranes comprised predominantly of specifically defined tetrabromobisphenols and aromatic dicarboxylic acids. The invention also pertains to the novel permeation processes for recovery of an oxygen/nitrogen or carbon dioxide/methane component from a mixture of said component with other components.

  主要由明确定义的四溴双酚和芳香族二羧酸组成的渗透膜。本发明还涉及从氧/氮或二氧化碳/甲烷组分与其他组分的混合物中回收该组分的新型渗透工艺。
• Chemically amplified radiation-sensitive composition
  申请人：OCG MICROELECTRONIC MATERIALS, INC.

  公开号：EP0697632A2

  公开（公告）日：1996-02-21

  A chemically amplified-type radiation-sensitive composition comprising: (a) an alkali-soluble binder resin made by a condensation reaction of: (i) hydroxystyrene moiety having formula [1] or [2]:    wherein x is an integer from 2 to 300; with (ii) a monomethylolated phenolic compound having a formula [8]:    wherein R₁ and R₂ are individually selected from the group consisting of lower alkyl group having 1-4 carbon atoms, lower alkoxy group having 1-4 carbon atoms, amino group, and carboxylic acid group;    wherein R₃ and R₄ are individually selected from the group consisting of hydrogen, lower alkyl group having 1-4 carbon atoms, lower alkoxy groups having 1-4 carbon atoms, an amino group, and a carboxylic group; and wherein a mole ratio of the hydroxy- styrene moiety to the monomethylolated phenolic compound is from about 1:10 to about 10:1; (b) at least one alkaline dissolution inhibitor containing acid-cleavable groups; and (c) at least one compound that results in generation of an acidic moiety under irradiation.

  一种化学放大型辐射敏感组合物，包括 (a) 一种碱溶性粘合剂树脂，由下列物质通过缩合反应制成 (i) 具有式[1]或[2]的羟基苯乙烯分子： 其中 x 为 2 至 300 的整数；与 (ii) 式[8]的单甲醇化酚类化合物： 其中 R₁ 和 R₂ 各自选自由 1-4 个碳原子的低级烷基、1-4 个碳原子的低级烷氧基、氨基和羧酸基组成的组； 其中 R₃ 和 R₄ 单独选自由氢、1-4 个碳原子的低级烷基、1-4 个碳原子的低级烷氧基、氨基和羧基组成的组；以及羟基苯乙烯分子与单甲醇化酚类化合物的摩尔比为约 1:10 至约 10:1； (b) 至少一种含有可酸解基团的碱性溶解抑制剂；以及 (c) 至少一种能在辐照下产生酸性分子的化合物。
• Photoresist compositions containing supercritical fluid fractionated polymeric binder resins
  申请人：OCG MICROELECTRONIC MATERIALS, INC.

  公开号：EP0727711A2

  公开（公告）日：1996-08-21

  A photoresist composition comprising either an admixture or a reaction product of: (a) at least one photosensitive compound selected from the group consisting of a photoactive compound, photo acid generators, and mixtures thereof; and (b) at least one polymeric binder resin fractionated with a supercritical fluid.

  一种光致抗蚀剂组合物，由以下物质的混合物或反应产物组成： (a) 至少一种光敏化合物，选自由光活性化合物、光酸生成物及其混合物组成的 组；以及 (b) 至少一种用超临界流体分馏的聚合物粘合剂树脂。
• Electro-optical device stable in the 600-1600 nanometer wavelength range
  申请人：Akzo Nobel N.V.

  公开号：EP0780722A1

  公开（公告）日：1997-06-25

  The present invention provides an electro-optical device comprising NLO polymer in the active layer with improved stability for light in the wavelength range of 600-1600 nm is guided through the device. The present invention is directed to an electro-optical device comprising two cladding layers and an active layer sandwiched between these cladding layers, with the active layer comprising a non-linear optically active side chain polymer with NLO-chromophores having an N-donor-delocated π system-acceptor structure, the N-donor not being bonded directly to alkyl groups. There are two ways to create NLO-chromophores with N-donors which do not have adjacent linear alkyl groups: The first way is to bond one or two aromatic groups. The N-atom is further bonded to the delocated π system. If only one aromatic group is present, the N-atom is, besides the delocated system, further bonded to a hydrogen or deuterium atom. The second way of avoiding adjacent alkyl groups is to employ an N-donor moiety wherein no adjacent linear alkyl groups are present.

  本发明提供了一种电光器件，该器件的有源层中包含 NLO 聚合物，在波长范围为 600-1600 纳米的光被引导通过该器件时，其稳定性有所提高。 本发明涉及一种电光器件，包括两个包层和夹在包层之间的有源层，有源层包括非线性光学活性侧链聚合物，其 NLO 色基具有 N-载体-脱位 π 系统-受体结构，N-载体不直接与烷基键合。 有两种方法可以制造出不具有相邻线性烷基的 N-质子的 NLO 色基： 第一种方法是键合一个或两个芳香基团。N 原子进一步键合到脱位的 π 系统上。如果只有一个芳香基团，则 N 原子除了与脱位体系结合外，还与氢原子或氘原子结合。 避免相邻烷基的第二种方法是采用不含相邻线性烷基的 N-供体分子。