(3S)-3-amino-N-naphthalen-1-ylbutanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-3-amino-N-naphthalen-1-ylbutanamide
• 化学式: C₁₄H₁₆N₂O
• 分子量: 228.29
• InChiKey: TWSVVHOUPYZFEY-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Dipeptidomimetics as inhibitors of human immunoproteasomes
  申请人：CORNELL UNIVERSITY

  公开号：US11202817B2

  公开（公告）日：2021-12-21

  The compounds of the present invention are represented by the following compounds having Formula I: where the substituents R1, R4, L, M, X, Y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having Formula (Ia), Formula (Ib), or Formula (Ic): where the substituents R1-R4, Rx, Ry, X, Y, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.

  本发明所述的化合物由以下具有式I的化合物表示： 其中，取代基R1、R4、L、M、X、Y和s的定义如本文所定义。本发明所述的化合物还由以下具有式(Ia)、式(Ib)或式(Ic)的化合物表示： 其中，取代基R1-R4、Rx、Ry、X、Y和s的定义如本文所定义。 这些化合物用于癌症、免疫系统疾病、自身免疫疾病、神经退行性疾病或炎症性疾病的治疗，或者用于移植器官或组织的免疫抑制。
• DIPEPTIDOMIMETICS AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES
  申请人：CORNELL UNIVERSITY

  公开号：US20180221431A1

  公开（公告）日：2018-08-09

  The compounds of the present invention are represented by the following compounds having Formula I, where the substituents R1, R4, L, M, X, Y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having Formula (Ia), Formula (Ib), or Formula (Ic), where the substituents R1-R4, RX, RY, X, Y, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
• [EN] DIPEPTIDOMIMETICS AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES<br/>[FR] DIPEPTIDOMIMETIQUES EN TANT QU'INHIBITEURS DES IMMUNOPROTEASOMES HUMAINS
  申请人：UNIV CORNELL

  公开号：WO2016028571A2

  公开（公告）日：2016-02-25

  The compounds of the present invention are represented by the following compounds having Formula (I), where the substituents R1, R4, L, M, X, Y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having Formula (Ia), Formula (lb), or Formula (Ic), where the substituents R1-R4, Rx, Ry, X, Y, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.