2',3'-O-cyclohexylidene-5-methyl-4'-C-[(methylthiomethyl)oxymethyl]-5'-O-pivaloyluridine | 1191255-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2',3'-O-cyclohexylidene-5-methyl-4'-C-[(methylthiomethyl)oxymethyl]-5'-O-pivaloyluridine
• 英文别名: [(3aS,4S,6R,6aR)-6-(5-methyl-2,4-dioxopyrimidin-1-yl)-4-(methylsulfanylmethoxymethyl)spiro[6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-2,1'-cyclohexane]-4-yl]methyl 2,2-dimethylpropanoate
• CAS: 1191255-91-0
• 化学式: C₂₄H₃₆N₂O₈S
• 分子量: 512.624
• InChiKey: LSVXHEXIAHPQDL-PDPLOHQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2',3'-O-cyclohexylidene-4'-C-(hydroxymethyl)-5-methyl-5'-O-pivaloyluridine 、 二甲基亚砜 在 4-甲基苯磺酸吡啶 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 反应 1.5h， 以49.5%的产率得到
  参考文献：
  名称：

  PROCESS FOR PRODUCTION OF ETHYNYLTHYMIDINE COMPOUND USING 5-METHYLURIDINE AS STARTING RAW MATERIAL

  摘要：

  公开号：

  EP2277878B1

文献信息

• PRODUCTION PROCESS OF ETHYNYLTHYMIDINE COMPOUNDS FROM 5-METHYLURIDINE AS A STARTING MATERIAL
  申请人：Sato Tatsunori

  公开号：US20110054164A1

  公开（公告）日：2011-03-03

  The present invention provides a process for producing 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine, which is useful as a medicine, in an efficient and industrially advantageous manner, and more specifically, provides a process for producing 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine as shown below. (wherein R 1 and R 2 independently represent a protective group for a hydroxy group, or R 1 and R 2 together form a protective group for two hydroxy groups, R 3 and R 4 independently represent a protective group for a hydroxy group, R 5 represents a protective group for a hydroxy group, R 6 represents a protective group for a hydroxy group, X represents a leaving group, and Y represents a halogen atom.)
• US8445669B2
  申请人：——

  公开号：US8445669B2

  公开（公告）日：2013-05-21
• PROCESS FOR PRODUCTION OF ETHYNYLTHYMIDINE COMPOUND USING 5-METHYLURIDINE AS STARTING RAW MATERIAL
  申请人：Hamari Chemicals, Ltd.

  公开号：EP2277878B1

  公开（公告）日：2014-09-17