para-vinylbenzylphosphonic acid | 53459-43-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: para-vinylbenzylphosphonic acid
• 英文别名: p-vinylbenzylphosphonic acid；4-vinylbenzylphosphonic acid；(4-Ethenylphenyl)methylphosphonic Acid
• CAS: 53459-43-1
• 化学式: C₉H₁₁O₃P
• 分子量: 198.158
• InChiKey: IJAOUFAMBRPHSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  para-vinylbenzylphosphonic acid 、 Acetamide, N-(4-iodophenyl)-2,2-bis[(1-methylethyl)thio]- 在 palladium diacetate 、 三乙胺 、 Dowex 50W 作用下， 以 乙腈 、 甲醇 、 水 为溶剂， 反应 24.0h， 生成 (4-{(E)-2-[4-(2,2-Bis-isopropylsulfanyl-acetylamino)-phenyl]-vinyl}-benzyl)-phosphonic acid
  参考文献：
  名称：

  COCHO-modified oxides nanoparticles by using phosphonic acid as grafting agent

  摘要：

  The synthesis of phosphonic acid 4 possessing a protected COCHO group, by using the Heck reaction is described. After grafting of the phosphonic acid 4 on metal oxides Al2O3, TiO2 or SnO2, the cleavage of the dithiane group was successful. The reactivity of the supported-COCHO group was examined by using model reactions with hydroxylamine and hydrazine derivatives. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01367-4
• 作为产物：
  描述：

  4-乙烯基苄基膦酸二乙酯 在 三甲基溴硅烷 、 水 作用下， 以 二氯甲烷 为溶剂， 以67%的产率得到para-vinylbenzylphosphonic acid
  参考文献：
  名称：

  对乙烯基苄基膦酸的合成和固态NMR研究。

  摘要：

  合成了对乙烯基苄基膦酸（2），并在两相A和B中结晶。后一相易于转化为前一相。通过IR和固态（31）P和（1）H NMR光谱以及X射线晶体学研究了这两个相。最近开发的NMR方法的使用使我们能够提高固态（1）H光谱通常较差的分辨率。这为质子环境提供了更多的见解。特别是，二维二维（1）H-（31）P异核相关（HETCOR）实验结合了Lee-Golburg同核去耦方案，可以描述A相和B相的混合物。

  DOI：

  10.1002/chem.200390086

文献信息

• Polymeric boronic acid derivatives as lipase inhibitors
  申请人：Huval Cori Chad

  公开号：US20060134062A1

  公开（公告）日：2006-06-22

  Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and a pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.

  人类肥胖是影响美国人口相当大比例的健康问题。已经开发了许多治疗肥胖的方法，但都存在严重缺陷。本发明揭示了一种新型聚合物类别，其在聚合物主链和挂链芳基硼酸基团之间具有硫原子或电子吸引基团。发现具有这种电子吸引基团的聚合物在体外和体内抑制脂肪酶特别有效。还公开了治疗肥胖和减少脂肪吸收��方法。
• DENTAL MATERIALS WITH DEBONDING-ON-DEMAND PROPERTIES
  申请人：Ivoclar Vivadent AG

  公开号：US20170156993A1

  公开（公告）日：2017-06-08

  Radically polymerizable dental material, which contains at least one compound of Formula I: and at least one thermolabile radically polymerizable compound and/or at least one photolabile radically polymerizable compound. The materials are characterized by debonding-on-demand properties.

  具有至少一种I式化合物的根本可聚合牙科材料，以及至少一种热敏根本可聚合化合物和/或至少一种光敏根本可聚合化合物。这些材料具有按需脱粘特性。
• Dental Materials on the Basis of Highly Acidic Polymerizable Bisphosphonic Acids
  申请人：IVOCLAR VIVADENT AG

  公开号：US20140296364A1

  公开（公告）日：2014-10-02

  The invention relates to a dental material which comprises a polymerizable bisphosphonic acid of Formula I: The invention also relates to the use of a polymerizable bisphosphonic acid of Formula I for the preparation of a dental material and in particular for the preparation of an adhesive, cement or composite.

  这项发明涉及一种包括化学式I的可聚合双膦酸的牙科材料。该发明还涉及使用化学式I的可聚合双膦酸制备牙科材料，特别是用于制备粘合剂、水泥或复合材料。
• DENTAL MATERIALS BASED ON MONOMERS HAVING DEBONDING-ON-DEMAND PROPERTIES
  申请人：Moszner Norbert

  公开号：US20140329929A1

  公开（公告）日：2014-11-06

  The invention relates to a dental restorative material which comprises a thermolabile or photolabile polymerizable compound of Formula I: [(Z 1 ) m -Q 1 -X)] k -T-[Y-Q 2 -(Z 2 ) n ] 1 Formula I, in which T represents a thermolabile or photolabile group, Z 1 and Z 2 in each case independently represent a polymerizable group selected from vinyl groups, CH 2 ═CR 1 —CO—O— and CH 2 ═CR 1 —CO—NR 2 — or an adhesive group selected from —Si(OR) 3 , —COOH, —O—PO(OH) 2 , —PO(OH) 2 , —SO 2 OH and —SH, wherein at least one Z 1 or Z 2 is a polymerizable group, Q 1 in each case independently is missing or represents an (m+1)-valent linear or branched aliphatic C 1 -C 20 radical which can be interrupted by —O—, —S—, —CO—O—, —O—CO—, —CO—NR 3 —, —NR 3 —CO—, —O—CO—NR 3 —, —NR 3 —CO—O— or —NR 3 —CO—NR 3 —, Q 2 in each case independently is missing or represents an (n+1)-valent linear or branched aliphatic C 1 -C 20 radical which can be interrupted by —O—, —S—, —CO—O—, —O—CO—, —CO—NR 3 —, —NR 3 —CO—, —O—CO—NR 3 —, —NR 3 —CO—O— or —NR 3 —CO—NR 3 —, X and Y in each case independently are missing or represent —O—, —S—, CO—O—, —O—CO—, —CO—NR 3 —, —NR 3 —CO—, —O—CO—NR 3 —, —NR 3 —CO—O— or —NR 3 —CO—NR 3 —, R, R 1 , R 2 and R 3 in each case independently represent H or a C 1 -C 7 alkyl radical and k, l, m and n in each case independently are 1, 2 or 3.

  该发明涉及一种牙科修复材料，包括具有以下化学式I的热敏性或光敏性可聚合化合物：[(Z1)m-Q1-X)]k-T-[Y-Q2-(Z2)n]1，在该式中，T代表热敏性或光敏性基团，Z1和Z2分别独立地代表从乙烯基、CH2═CR1—CO—O—和CH2═CR1—CO—NR2—中选择的可聚合基团，或从—Si(OR)3、—COOH、—O—PO(OH)2、—PO(OH)2、—SO2OH和—SH中选择的粘附基团，其中至少一个Z1或Z2是可聚合基团，Q1分别独立地缺失或代表一个(m+1)-价的线性或支链脂肪族C1-C20基团，该基团可以通过—O—、—S—、—CO—O—、—O—CO—、—CO—NR3—、—NR3—CO—、—O—CO—NR3—、—NR3—CO—O—或—NR3—CO—NR3—中断，Q2分别独立地缺失或代表一个(n+1)-价的线性或支链脂肪族C1-C20基团，该基团可以通过—O—、—S—、—CO—O—、—O—CO—、—CO—NR3—、—NR3—CO—、—O—CO—NR3—、—NR3—CO—O—或—NR3—CO—NR3—中断，X和Y分别独立地缺失或代表—O—、—S—、CO—O—、—O—CO—、—CO—NR3—、—NR3—CO—、—O—CO—NR3—、—NR3—CO—O—或—NR3—CO—NR3—，R、R1、R2和R3分别独立地代表H或C1-C7烷基基团，k、l、m和n分别独立地为1、2或3。
• Bis(2-acenyl)acetylene semiconductors
  申请人：Gerlach P. Christopher

  公开号：US20050012090A1

  公开（公告）日：2005-01-20

  Bis(2-acenyl)acetylene compounds that are useful as organic semiconductors are disclosed. The compounds, when used as the active layer in OTFTs exhibit device characteristics, like charge-carrier mobilities and current on/off ratios, that are comparable to those of pentacene. Also described are semiconductor devices comprising at least one compound of the invention; and articles comprising the semiconductor devices such as thin film transistors or transistor arrays, and electroluminescent lamps.

  本发明揭示了作为有机半导体有用的双(2-芴基)乙炔化合物。当这些化合物作为OTFTs中的活性层时，表现出与五环芴相当的器件特性，如载流子迁移率和开关比。还描述了包括本发明至少一种化合物的半导体器件；以及包括半导体器件的物品，如薄膜晶体管或晶体管阵列，以及电致发光灯。