4-Benzyloxyphenyl-2-pyridylcarbinol | 33455-93-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-Benzyloxyphenyl-2-pyridylcarbinol
• 英文别名: (4-benzyloxy-phenyl)-pyridin-2-yl-methanol；[4-(Benzyloxy)phenyl](pyridin-2-yl)methanol；(4-phenylmethoxyphenyl)-pyridin-2-ylmethanol
• CAS: 33455-93-5
• 化学式: C₁₉H₁₇NO₂
• 分子量: 291.349
• InChiKey: YOILQUBEESMTOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Amino alcohol-boron-binol complex and method for preparing optically active amino alcohol derivative by using same
  申请人：MOLECULES & MATERIALS CO., LTD.

  公开号：US11130734B2

  公开（公告）日：2021-09-28

  Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enationselective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.

  本发明公开了一种作为中间体的氨基醇-硼-比醇络合物（包括下图所示的络合物 3-1-1），以及使用该络合物制备光学活性氨基醇的方法，其中使用硼化合物和(R)-或(S)-比醇以烯化选择性方式解析外消旋氨基醇，从而可以高产率制备出光学纯度高的氨基醇衍生物。
• AMINO ALCOHOL-BORON-BINOL COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE AMINO ALCOHOL DERIVATIVE BY USING SAME
  申请人：MOLECULES & MATERIALS CO., LTD.

  公开号：US20210206719A1

  公开（公告）日：2021-07-08

  Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enation selective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.