3-[(2-methylpropan-2-yl)oxycarbonylamino]-5-methylsulfanyl-pentanoic Acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-[(2-methylpropan-2-yl)oxycarbonylamino]-5-methylsulfanyl-pentanoic Acid
• 英文别名: 3-[(2-methylpropan-2-yl)oxycarbonylamino]-5-methylsulfanylpentanoic acid
• 化学式: C₁₁H₂₁NO₄S
• 分子量: 263.36
• InChiKey: HBFKPNZCUUZRLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• QUINOLYL PYRROLO PYRIMIDYL CONDENSED-RING COMPOUND AND SALT THEREOF
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：US20140057899A1

  公开（公告）日：2014-02-27

  The present invention provides a new compound that has an inhibitory action against EGFR and that has cell growth inhibitory effects. The present invention further provides a pharmaceutical preparation useful for preventing and/or treating cancer, based on the EGFR inhibitory effect of the compound. A compound represented by the following Formula (I) or a salt thereof.

  本发明提供了一种对EGFR具有抑制作用并具有细胞生长抑制作用的新化合物。本发明还提供了一种药物制剂，可根据该化合物的EGFR抑制作用用于预防和/或治疗癌症。由下式（I）表示的化合物或其盐。
• NOVEL QUINOLINE -SUBSTITUTED COMPOUND
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20160194332A1

  公开（公告）日：2016-07-07

  An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.

  本发明的目标是提供一种具有EGFR抑制作用和细胞生长抑制作用的新化合物，以及一种基于EGFR抑制作用的用于预防和/或治疗癌症的药物。本发明提供以下式（I）所代表的化合物或其盐。
• NOVEL QUINOLINE-SUBSTITUTED COMPOUND
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3037424A1

  公开（公告）日：2016-06-29

  An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.

  本发明要达到的一个目的是提供一种具有表皮生长因子受体抑制作用和细胞生长抑制作用的新型化合物，以及一种基于表皮生长因子受体抑制作用的用于预防和/或治疗癌症的药物。 本发明提供了由下式(I)代表的化合物或其盐。
• QUINOLYLPYRROLOPYRIMIDYL FUSED-RING COMPOUND OR SALT THEREOF
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP2722332B1

  公开（公告）日：2016-04-20
• US8889666B2
  申请人：——

  公开号：US8889666B2

  公开（公告）日：2014-11-18