N-(2,5-二氯苯基)-2-甲基-丙酰胺 | 90919-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2,5-二氯苯基)-2-甲基-丙酰胺
• 英文名称: N-(2,5-dichlorophenyl)-t-butylamide
• 英文别名: N-(2,5-dichlorophenyl)-2-methylpropanamide
• CAS: 90919-83-8
• 化学式: C₁₀H₁₁Cl₂NO
• mdl: MFCD00751784
• 分子量: 232.109
• InChiKey: VOCOLIKSFJGAIB-UHFFFAOYSA-N

物化性质

• 熔点：
  137-139 °C
• 沸点：
  360.2±32.0 °C(Predicted)
• 密度：
  1.290±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  三甲基乙酸酐 在 盐酸 、 硫酸 作用下， 生成 N-(2,5-二氯苯基)-2-甲基-丙酰胺
  参考文献：
  名称：

  Herbicidal 3-(substituted benzoxazol-7-yl) and 3-(Substituted

  摘要：

  本发明揭示了除草剂3-(取代苯并噁唑-7-基)和3-(取代苯并噻唑-7-基)-1-取代-6-三氟甲基-2,4-(1H,3H)嘧啶二酮，包含它们的组合物，以及使用它们控制不受欢迎的植物生长的方法，还公开了用于制备这些化合物的新型中间体。本发明的除草剂化合物由以下通用结构定义： R是从各种取代基中选择的，包括卤素、烷基、烯基、炔基、苯基、苯基烷基、烷基苯基烷基、卤代烷基、羟基、烷氧基、羟基烷基、卤代苯基、卤代苯基烷基、烷氧基苯基、硫醇基、烷基硫基、哌啶基、烷基氨基、烷氧基烷基、苯氧基、氨基、烷基磺酰氨基、苯基磺酰氨基和羧基；R^1是烷基或氨基；R^2是氢或卤素；X是氧或硫；Y是氢、卤素、烷氧基、氰基或硝基；Z是卤素；其中卤素是溴、氯、氟或碘，每个烷基、烷氧基、烯基或炔基基团具有一至六个碳原子。

  公开号：

  US05753595A1

文献信息

• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。
• Therapeutic compounds and uses thereof
  申请人：GENENTECH, INC.

  公开号：US10206931B2

  公开（公告）日：2019-02-19

  The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

  本发明涉及式（I）化合物： 及其盐，其中 A 具有说明书中定义的任一值，以及其组合物和用途。这些化合物可用作 CBP 和/或 EP300 的抑制剂。还包括包含式（I）化合物或其药学上可接受的盐的药物组合物，以及使用此类化合物和盐治疗各种CBP和/或EP300介导的疾病的方法。
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：GENENTECH, INC.

  公开号：US20170312292A1

  公开（公告）日：2017-11-02

  The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
• US7342016B2
  申请人：——

  公开号：US7342016B2

  公开（公告）日：2008-03-11
• Herbicidal 3-(substituted benzoxazol-7-yl) and 3-(Substituted
  申请人：FMC Corporation

  公开号：US05753595A1

  公开（公告）日：1998-05-19

  Herbicidal 3-(substituted benzoxazol-7-yl) and 3-(substituted benzothiazol-7-yl)-1 -substituted-6-trifluoromethyl-2,4-(1H,3H)pyrimidinediones, compositions containing them, and methods of using them to control undesired plant growth are disclosed, as are novel intermediates used in the preparation of these compounds. The herbicidal compounds of the present invention are defined by the following generic structure: ##STR1## in which R is selected from a variety of substituents, including halogen, alkyl, alkenyl, alkynyl, phenyl, phenylalkyl, alkylphenylalkyl, haloalkyl, hydroxy, alkoxy, hydroxyalkyl, halophenyl, halophenylalkyl, alkoxyphenyl, sulfhydryl, alkylthio, piperidinyl, alkylamino, alkoxyalkyl, phenoxy, amino, alkylsulfonylamino, phenylsulfonylamino, and carboxy; R.sup.1 is alkyl or amino; R.sup.2 is hydrogen or halogen; X is oxygen or sulfur; Y is hydrogen, halogen, alkoxy, cyano, or nitro, and; Z is halogen; where halogen is bromine, chlorine, fluorine, or iodine, and each alkyl, alkoxy, alkenyl, or alkynyl moiety has one to six carbon atoms.

  本发明揭示了除草剂3-(取代苯并噁唑-7-基)和3-(取代苯并噻唑-7-基)-1-取代-6-三氟甲基-2,4-(1H,3H)嘧啶二酮，包含它们的组合物，以及使用它们控制不受欢迎的植物生长的方法，还公开了用于制备这些化合物的新型中间体。本发明的除草剂化合物由以下通用结构定义： R是从各种取代基中选择的，包括卤素、烷基、烯基、炔基、苯基、苯基烷基、烷基苯基烷基、卤代烷基、羟基、烷氧基、羟基烷基、卤代苯基、卤代苯基烷基、烷氧基苯基、硫醇基、烷基硫基、哌啶基、烷基氨基、烷氧基烷基、苯氧基、氨基、烷基磺酰氨基、苯基磺酰氨基和羧基；R^1是烷基或氨基；R^2是氢或卤素；X是氧或硫；Y是氢、卤素、烷氧基、氰基或硝基；Z是卤素；其中卤素是溴、氯、氟或碘，每个烷基、烷氧基、烯基或炔基基团具有一至六个碳原子。