N,2,2-trimethylbutanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,2,2-trimethylbutanamide
• 化学式: C₇H₁₅NO
• mdl: MFCD02860318
• 分子量: 129.2
• InChiKey: WUAHBBHXEMXBET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF
  申请人：Keck Gary E.

  公开号：US20110269713A1

  公开（公告）日：2011-11-03

  Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.

  本文描述的是三环大环内酯。这些大环内酯对蛋白激酶C（PKC）具有很高的结合亲和力。本文描述的化合物可用于多种治疗应用，包括癌症和阿尔茨海默病的预防和治疗。本文描述的化合物还可以用于治疗记忆丧失。本文还描述了生产大环内酯的方法。这些方法允许在更少的步骤中以更高的置换度和特异性高产合成大环内酯。
• [EN] INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION<br/>[FR] INHIBITEURS DE LA REPLICATION DU VIRUS DE L'IMMUNODEFICIENCE HUMAINE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010130034A1

  公开（公告）日：2010-11-18

  Compounds of formula I wherein a, R1, R2, R3, R4, R5 and R6 are defined herein, are useful as inhibitors of HIV replication.

  式I中的化合物，其中a、R1、R2、R3、R4、R5和R6如本文所定义，可用作HIV复制抑制剂。
• Antibacterial Agent, Substrate Surface Treatment Method Using The Same, Antibacterial Agent Composition, And Substrate Surface Treatment Method Using The Same
  申请人：Komoriya Haruhiko

  公开号：US20130189220A1

  公开（公告）日：2013-07-25

  [Problem] To provide an antibacterial agent which can be limited to the required location on the surface of a material without mixing and has excellent antibacterial, antifungal and antiviral effects even at low concentrations of the active component without elution or volatilization. [Solution] An antibacterial agent that contains as an active component a resin having an organic group represented by general formula (I-1). (In the formula (I-1), R 1 and R 2 mutually independently represent a C 1 -C 4 fluoroalkyl group. “C” and “A” are bonded to each other through a covalent bond or an ionic bond, and “A” represents a hydrogen atom or a cation.)

  [问题] 提供一种抗菌剂，可以将其限制在材料表面的所需位置，而不混合，并且即使在活性成分低浓度下也具有出色的抗菌，抗真菌和抗病毒效果，而不会出现溶出或挥发。 [解决方案] 一种抗菌剂，其包含有机基团为通式（I-1）所表示的树脂作为活性成分。（在通式（I-1）中，R1和R2互相独立地表示C1-C4氟代烷基。 “C”和“A”通过共价键或离子键彼此连接，“A”表示氢原子或阳离子。）
• Shape memory polymers
  申请人：Anthamatten Mitchell L.

  公开号：US20080177303A1

  公开（公告）日：2008-07-24

  The present disclosure relates to Shape Memory Polymers (SMP's) comprising function groups that allow the polymers to be elastically deformed, utilized in the elastically deformed state, and subsequently returned to the original polymorphic shape.

  本公开涉及形状记忆聚合物（SMP），其中包含允许聚合物弹性变形的功能基团，可在弹性变形状态下使用，并随后返回到原始的多态形状。
• 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS
  申请人：Hutchinson Howard John

  公开号：US20070219206A1

  公开（公告）日：2007-09-20

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

  本文描述了一些化合物和含有这些化合物的制药组合物，这些化合物可以调节5-脂氧合酶激活蛋白（FLAP）的活性。本文还描述了使用这种FLAP调节剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他依赖于白三烯或介导白三烯的疾病或病症。