2-[2-Aminoethyl-[2-(4-amino-2-oxopyrimidin-1-yl)acetyl]amino]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-Aminoethyl-[2-(4-amino-2-oxopyrimidin-1-yl)acetyl]amino]acetic acid
• 化学式: C₁₀H₁₅N₅O₄
• 分子量: 269.26
• InChiKey: MFPUAOSBORLXTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：The Johns Hopkins University

  公开号：US20210094933A1

  公开（公告）日：2021-04-01

  The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

  本公开提供了受免疫蛋白配体家族FK506和雷帕霉素天然产物启发的大环化合物。生成包含FK506和雷帕霉素结合结构域的Rapafucin大环化合物库，应具有作为治疗疾病新药的潜力。
• Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids ("PNAs") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
  申请人：Becker L. Matthew

  公开号：US20060159619A1

  公开（公告）日：2006-07-20

  A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.

  一种功能性生物活性颗粒共轭物，用于诊断和治疗癌症，作为生物门户，包括与之相关联的细胞内靶向配体，包括PNA或其他核酸酶抵抗性寡核苷酸类似物，如MOE-mRNA（2'-甲氧基乙基mRNA）或LNA（锁定核酸），具有选择性结合于哺乳动物体内癌症或疾病状态特异性表达或过表达的mRNA序列。在一个方面，特异性过表达的靶点是unr mRNA，可以通过反义序列PNA50进行靶向。
• Somatostatin-dopamine chimeric analogs
  申请人：IPSEN PHARMA

  公开号：EP2062914A2

  公开（公告）日：2009-05-27

  Disclosed is a series of dopamine analogs and pharmaceutical compositions comprising the same.

  所公开的是一系列多巴胺类似物及其药物组合物。
• Somatostatin vectors
  申请人：IPSEN PHARMA

  公开号：EP2662087A1

  公开（公告）日：2013-11-13

  The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions.

  本发明的特点是靶向细胞毒性化合物及其用于治疗肿瘤和其他疾病的方法。
• Tolan compound
  申请人：OSAKA UNIVERSITY

  公开号：US10577396B2

  公开（公告）日：2020-03-03

  An object of the present invention is to conduct a search for a compound to be arranged at a terminal of a peptide nucleic acid effective in detecting a single nucleotide polymorphism. Provided is a tolan compound represented by the following formula (1): wherein R1 represents a phenyl group or a naphthyl group, the phenyl group may have 1 to 5 substituents that are identical to or different from each other, and the naphthyl group may have 1 to 7 substituents that are identical to or different from each other.

  本发明的目的是寻找一种化合物，将其排列在肽核酸的末端，可有效地检测单核苷酸多态性。本发明提供了一种由下式（1）表示的托兰化合物： 其中 R1 代表苯基或萘基，苯基可以有 1 至 5 个彼此相同或不同的取代基，萘基可以有 1 至 7 个彼此相同或不同的取代基。