2-methyl-N-(propan-2-yl)pentanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methyl-N-(propan-2-yl)pentanamide
• 英文别名: 2-methyl-N-propan-2-ylpentanamide
• 化学式: C₉H₁₉NO
• mdl: MFCD02860408
• 分子量: 157.25
• InChiKey: REBUELJWPORYQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• BORON-CONTAINING SMALL MOLECULES
  申请人：Baker Stephen J.

  公开号：US20100267981A1

  公开（公告）日：2010-10-21

  This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

  本发明涉及用于治疗真菌感染的化合物，更具体地用于治疗甲真菌病和/或皮肤真菌感染的局部治疗。本发明涉及对真菌具有活性并具有性质的化合物，使得当将化合物置于患者接触的特定皮肤、指甲、毛发、爪或蹄部位感染的真菌处时，化合物能够到达该部位。特别地，本发明所述的化合物具有物理化学性质，有利于穿透指甲板。
• PHARMACEUTICAL FORMULATIONS
  申请人：Anacor Pharmaceuticals, Inc.

  公开号：US20130210770A1

  公开（公告）日：2013-08-15

  This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

  本发明涉及用于治疗真菌感染的化合物，更具体地用于治疗甲真菌病和/或皮肤真菌感染的局部治疗。本发明针对的是对真菌活性的化合物，并具有使化合物在与患者接触时能够到达真菌感染的皮肤、指甲、头发、爪或蹄的特定部位的特性。特别是，本发明的化合物具有物理化学性质，有助于穿透指甲板。
• Boron-containing small molecules
  申请人：Baker J. Stephen

  公开号：US20070155699A1

  公开（公告）日：2007-07-05

  This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

  本发明涉及用于治疗真菌感染的化合物，更具体地用于治疗甲真菌病和/或皮肤真菌感染的局部治疗。本发明涉及的化合物对真菌具有活性，并具有使化合物与患者接触时能够到达被真菌感染的皮肤、指甲、头发、爪或蹄的特定部位的特性。特别是，本发明的化合物具有物理化学特性，有利于穿透指甲板。
• BICYCLIC PYRAZOLONE COMPOUNDS AND METHODS OF USE
  申请人：CALITOR SCIENCES, LLC

  公开号：US20170183358A1

  公开（公告）日：2017-06-29

  The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases, especially Axl, Mer, c-Met and Ron. The invention also provides pharmaceutical compositions comprising the compound disclosed herein, and a method of preventing, treating or lessening the severity of a proliferative disorder in a patient with the compounds or the pharmaceutical compositions disclosed herein.
• KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
  申请人：Icahn School of Medicine at Mount Sinai

  公开号：US20210094950A1

  公开（公告）日：2021-04-01

  Described herein are compounds having the following structure: formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof. Also disclosed are compositions containing the compounds, methods of inhibiting activity of DYRK1 A in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.