2-[[4-[[3-Methyl-1-oxo-1-[2-[(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamoyl]benzoyl]amino]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[4-[[3-Methyl-1-oxo-1-[2-[(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamoyl]benzoyl]amino]acetic acid
• 化学式: C₂₆H₃₃F₃N₄O₇
• 分子量: 570.6
• InChiKey: MRTSIBBMOWLRPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  162
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• EXTERNAL PREPARATION FOR SKIN FOR WRINKLE IMPROVEMENT
  申请人：Pola Chemical Industries Inc.

  公开号：EP3476381A1

  公开（公告）日：2019-05-01

  A method for improving dermal retentivity of a compound, which compound is effective for prevention or improvement of skin aging, is provided. The oil-gel-form external preparation for skin containing: 1) a compound represented by the following General Formula (1), an isomer thereof, and/or a pharmaceutically acceptable salt thereof; and 2) a partially cross-linked methyl polysiloxane; of the present invention allows easy penetration of the effective component of 1) from the preparation into the skin while enhancing the percutaneous absorbability and improving the intradermal retentivity. [In the formula, R1 represents a C1-C4 linear or branched alkyl group substituted by a carboxyl group(s), or a C1-C4 linear or branched alkyl group substituted by a carboxylic acid ester group(s) having a C1-C4 alkyl chain, and R2 and R3 each independently represent a C1-C4 linear or branched alkyl group.]

  本发明提供了一种提高化合物皮肤保持力的方法，该化合物可有效预防或改善皮肤老化。本发明的油凝胶状皮肤外用制剂含有：1）由以下通式（1）代表的化合物、其异构体和/或其药学上可接受的盐；和 2）部分交联的甲基聚硅氧烷；该制剂可使 1）中的有效成分容易地从制剂中渗透到皮肤中，同时提高经皮吸收性并改善皮内保持力。 [式中，R1 代表被羧基取代的 C1-C4 直链或支链烷基，或被具有 C1-C4 烷基链的羧酸酯基取代的 C1-C4 直链或支链烷基，R2 和 R3 各自独立地代表 C1-C4 直链或支链烷基。
• OIL-BASED COMPOSITION
  申请人：Pola Chemical Industries Inc.

  公开号：EP3711746A1

  公开（公告）日：2020-09-23

  Provided is a method for blending a compound effective in preventing or improving skin aging with a composition in a chemically stable manner. Also provided is a method for increasing the uniform dispersibility of the compound in the composition. A compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof is dispersed in an oiling agent having 0 to 2 hydroxy groups to prepare an oil-based composition, thereby suppressing the decomposition of the compound. Moreover, the composition further contains a powder, a solid fat and/or a semi-solid fat, thereby suppressing the sedimentation of the compound in the composition over time. [In formula (1), R1 represents a linear or branched C1-4 alkyl group substituted with a carboxyl group or a linear or branched C1-4 alkyl group substituted with a carboxylic acid ester group having a C1-4 alkyl chain, and R2 and R3 each independently represent a linear or branched C1-4 alkyl group.]

  本发明提供了一种以化学稳定的方式将有效防止或改善皮肤老化的化合物与组合物混合的方法。还提供了一种提高化合物在组合物中均匀分散性的方法。将以下通式（1）代表的化合物、其异构体和/或其药理上可接受的盐分散在具有 0 至 2 个羟基的油剂中，制备油基组合物，从而抑制化合物的分解。此外，该组合物还含有粉末、固体脂肪和/或半固体脂肪，从而抑制化合物在组合物中随时间的沉淀。 [在式 (1) 中，R1 代表被羧基取代的直链或支链 C1-4 烷基，或被具有 C1-4 烷基链的羧酸酯基取代的直链或支链 C1-4 烷基，R2 和 R3 各自独立地代表直链或支链 C1-4 烷基。］