4-Hydroxy-5-sulfooxyoxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-Hydroxy-5-sulfooxyoxane-2-carboxylic acid
• 化学式: C₆H₁₀O₈S
• 分子量: 242.21
• InChiKey: IRTONBQROPNEJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  139
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
  申请人：KOVI Ravishanker

  公开号：US20130005954A1

  公开（公告）日：2013-01-03

  Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.

  公开了合成因子Xa抗凝剂磺达肝癸钠及其相关化合物的方法。提供了受保护的五糖中间体以及通过一系列去保护和磺化反应将受保护五糖中间体转化为磺达肝癸钠的工业规模生产的高效和可扩展过程。
• ANTICOAGULANT REVERSAL AGENTS
  申请人：PEROSPHERE INC.

  公开号：US20170056396A1

  公开（公告）日：2017-03-02

  Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods of using the compounds to reverse the anticoagulant effects of coagulation inhibitors, and diagnostic assays comprising the compounds.

  揭示了新型抗凝血逆转化合物，以及制备该化合物的方法，包括该化合物的制药组合物，使用该化合物逆转凝血抑制剂的抗凝血效果的方法，以及包含该化合物的诊断测定方法。
• Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
  申请人：Casu Benito

  公开号：US20080139503A1

  公开（公告）日：2008-06-12

  Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R 1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
• Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
  申请人：Viskov Christian

  公开号：US20080318328A1

  公开（公告）日：2008-12-25

  The invention provides a process for preparing heparin products with a reduced content of glycoserine. A method for detecting glycoserine in preparations of heparin is also provided.
• GLYCOSAMINOGLYCANS DERIVED FROM K5 POLYSACCHARIDE HAVING HIGH ANTICOAGULANT AND ANTITHROMBOTIC ACTIVITIES AND PROCESS FOR THEIR PREPARATION
  申请人：ORESTE Pasqua A.

  公开号：US20110281820A1

  公开（公告）日：2011-11-17

  Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activity and useful for the control of coagulation and as antithrombotic agents are obtained starting from an optionally purified K5 polysaccharide by a process comprising the steps of N-deacetylation/N-sulfation, C5 epimerization, O-oversulfation, selective O-desulfation, 6-O-sulfation, N-sulfation, and optional depolymerization, in which said epimerization is performed with the use of the enzyme glucoronosyl C5 epimerase in solution or in immobilized form in the presence of divalent cations. New, particularly interesting antithrombin compounds are obtained by controlling the reaction time in the selective O-desulfation step and submitting the product obtained at the end of the final N-sulfation step to depolymerization.