2,6-Dioxo-adamantane-1,3,5,7-tetracarboxylic acid | 40460-17-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,6-Dioxo-adamantane-1,3,5,7-tetracarboxylic acid
• 英文别名: 2,6-Dioxo-1,3,5,7-adamantanetetracarboxylic acid；2,6-dioxoadamantane-1,3,5,7-tetracarboxylic acid
• CAS: 40460-17-1
• 化学式: C₁₄H₁₂O₁₀
• 分子量: 340.243
• InChiKey: CWNMLUDMKYTMQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  183
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  2,6-Dioxo-adamantane-1,3,5,7-tetracarboxylic acid 在 碘苯二乙酸 、 碘 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以48%的产率得到1,3,5,7-tetraiodoadamantan-2,6-dione
  参考文献：
  名称：

  Alternative syntheses of the D2d symmetric 1,3,5,7-tetraiodotricyclo[3.3.0.03,7]octane

  摘要：

  Three alternative syntheses of 1,3,5,7-tetraiodotricyclo[3.3.0.0(3,7)] octane are described. Reaction of this tetraiodide with sodium amalgam in the presence of dienes or with molten sodium in boiling 1,4-dioxane in the absence of trapping agents led to very complex mixtures of products, presumably due to competitive 1,2- and 1,3-deiodination reactions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.05.015

文献信息

• MOISEEV I. K.; MRATXUZINA T. A.; BELYAEV P. G.; NAFIKOV G. F.; TKACHEVA E+, ZH. ORGAN. XIMII, 1979, 15, HO 11, 2341-2344
  作者：MOISEEV I. K.、 MRATXUZINA T. A.、 BELYAEV P. G.、 NAFIKOV G. F.、 TKACHEVA E+

  DOI：——

  日期：——
• MOISEEV, I. K.;KONOVALOVA, V. P., XIMIYA GETEROTSIKL. SOEDIN., 1982, N 4, 528-531
  作者：MOISEEV, I. K.、KONOVALOVA, V. P.

  DOI：——

  日期：——
• NUCLEAR EXPORT INHIBITORS OF TOPOISOMERASE II ALPHA
  申请人：Sullivan Daniel M.

  公开号：US20110275581A1

  公开（公告）日：2011-11-10

  A method of treating cancer in a subject comprising the step of administering to the subject in need thereof an effective amount of a combination of a compound that binds a nuclear export signal (NES inhibitor) on topoisomerase IIα and a topoisomerase inhibitor. Twenty small molecule inhibitors (SMI) that bind to the two nuclear export sequences (NES) topo IIα have been identified from the NCI database using computer-generated molecular modeling. These SMI will improve the effectiveness of topo II directed therapeutics, particularly in the treatment of diseases such as multiple myeloma (MM). In vitro apoptosis assays indicate that these drugs may be effective as single agents or in combination with currently used cancer drugs that target topo II.
• US8623854B2
  申请人：——

  公开号：US8623854B2

  公开（公告）日：2014-01-07
• [EN] NUCLEAR EXPORT INHIBITORS OF TOPOISOMERASE II ALPHA<br/>[FR] INHIBITEURS D'EXPORT NUCLÉAIRE DE TOPOISOMÉRASE II ALPHA
  申请人：H LEE MOFFITT CANCER CT AND RE

  公开号：WO2010068947A2

  公开（公告）日：2010-06-17

  A method of treating cancer in a subject comprising the step of administering to the subject in need thereof an effective amount of a combination of a compound that binds a nuclear export signal (NES inhibitor) on topoisomerase Na and a topoisomerase inhibitor. Twenty small molecule inhibitors (SMI) that bind to the two nuclear export sequences (NES) topo IIα have been identified from the NCI database using computer-generated molecular modeling. These SMI will improve the effectiveness of topo Il directed therapeutics, particularly in the treatment of diseases such as multiple myeloma (MM). In vitro apoptosis assays indicate that these drugs may be effective as single agents or in combination with currently used cancer drugs that target topo N.