N-(2-(二甲基氨基)乙基)甲酰胺 | 7249-51-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(2-(二甲基氨基)乙基)甲酰胺
• 英文名称: Dimethyl-β-formylaminoethylamine
• 英文别名: N-(2-(dimethylamino)ethyl)formamide；N-(2-dimethylamino-ethyl)-formamide；N-(2-Dimethylamino-aethyl)-formamid；N-(2-dimethylamino-ethyl)-formamide；N-(2-dimethylaminoethyl)formamide；N-[2-(dimethylamino)ethyl]formamide
• CAS: 7249-51-6
• 化学式: C₅H₁₂N₂O
• 分子量: 116.163
• InChiKey: LUYKQNSSAITKCU-UHFFFAOYSA-N

物化性质

• 沸点：
  130-132 °C(Press: 19 Torr)
• 密度：
  0.933±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N-(2-(二甲基氨基)乙基)甲酰胺 在 lithium aluminium tetrahydride 作用下， 生成 N-[2-(dimethylamino)ethyl]-N,2-dimethylbenzamide
  参考文献：
  名称：

  Long-range anisotropic effects of long chain amides

  摘要：

  DOI：

  10.1007/bf00899784
• 作为产物：
  描述：

  N,N-二甲基乙二胺 、 甲酸乙酯 在 air 作用下， 反应 24.0h， 以77%的产率得到N-(2-(二甲基氨基)乙基)甲酰胺
  参考文献：
  名称：

  Amide-Ligand-Controlled Highly para-Selective Arylation of Monosubstituted Simple Arenes with Arylboronic Acids

  摘要：

  Pd-catalyzed highly para-selective arylations of monosubstituted simple arenes with arylboronic acids to widely existed biaryls have been developed. Inspired by requisite amide-directing groups in reported selective oxidative couplings, amide ligands, especially DMF, are designed and found to be critical for the selectivity control in current arylations.

  DOI：

  10.1021/jacs.6b12907

文献信息

• Benzimidazoles useful as angiotensin-11 antagonists
  申请人：Dr. Karl Thomae GmbH

  公开号：US05591762A1

  公开（公告）日：1997-01-07

  Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: (a) 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1-yl] methyl]-biphenyl-2-carboxylic acid.

  本文披露了以下结构的血管紧张素II拮抗剂##STR1##其中R.sub.1是氢以外的其他官能团，包括卤素、较低的烷基或环烷基；R.sub.2是可选择地取代的苯并咪唑-2-基、5,6,7,8-四氢咪唑并[1,2-a]吡啶-2-基、丁磺酰胺-1-基、咪唑-4-基和四氢苯并咪唑-2-基等；R.sub.3是较低的烷基；R.sub.4是酸性基团，如羧基或四唑基。一个示例化合物是：(a) 4'-[[2-正丙基-4-甲基-6-(1-甲基苯并咪唑-2-基)-苯并咪唑-1-基] 甲基]-联苯-2-羧酸。
• Azo dyestuff intermediate nitro- or aminobenzenes ring-substituted by a
  申请人：Sterling Drug Inc.

  公开号：US04146558A1

  公开（公告）日：1979-03-27

  Water-soluble cationic dyestuffs of the formulae ##STR1## WHEREIN R.sup.0 is hydrogen, lower-alkyl or hydroxy-lower-alkyl; R.sup.1 is lower-alkyl, lower-alkenyl or hydroxy-lower-alkyl; R.sup.2 is lower-alkyl, lower-alkenyl, hydroxy-lower-alkyl or -(lower-alkylene)-NR.sup.0 Y or R.sup.1 and R.sup.2 together with the nitrogen atom, are pyrrolidino, piperidino or 4-lower-alkanoyl piperazino; Y is hydrogen or ##STR2## wherein R is hydrogen, lower-alkyl, lower-alkenyl, phenyl or phenyl-lower-alkyl; A is a member selected from the group consisting of an aromatic azo dyestuff residue attached to the quaternary ammonium nitrogen atom through a lower-alkylene bridge. K is a small integer whose value is dependent on the nature of A such that it has a range from one to two; R.sup.8 is lower-alkyl, lower-alkenyl or hydroxy-lower-alkyl; R.sup.9 is lower-alkyl, hydroxy-lower-alkyl or NH.sub.2 ; R.sup.10 is lower-alkyl or lower-alkenyl; A.sup.1 is an aromatic azo dyestuff residue attached to the quaternary ammonium nitrogen atom through a lower-alkylene bridge; G is a small integer whose value is dependent on the nature of A.sup.1 such that it has a range from one to two; R.sup.8 ' is lower-alkyl; R.sup.9 ' is lower-alkyl, lower-alkenyl or hydroxy-lower-alkyl; R.sup.10 ' is lower-alkyl, lower-alkenyl or hydroxy-lower-alkyl or R.sup.9 ' and R.sup.10 ' together with the nitrogen atom are morpholino; A.sup.2 is an aromatic azo dyestuff residue attached to the quaternary ammonium nitrogen atom through a lower-alkylene bridge; h is a small integer whose value is dependent on the nature of A.sup.2 such that it has a range from one to two; and An is an anion are particularly useful for coloring natural fibers, synthetic fiber-forming materials and cellulosic materials. These dyes dye cotton and paper various shades of stable yellows, reds and oranges. The dyeing from these dyes on paper are less prone to bleed and have a high degree of color discharge when bleached with hypochlorite or chlorine bleaches.

  水溶性阳离子染料的化学式为##STR1## 其中R.sup.0为氢、较低烷基或羟基较低烷基；R.sup.1为较低烷基、较低烯烃基或羟基较低烷基；R.sup.2为较低烷基、较低烯烃基、羟基较低烷基或-(较低烷基)-NR.sup.0 Y或R.sup.1和R.sup.2与氮原子一起，为吡咯烷基、哌啶基或4-较低酰基哌嗪基；Y为氢或##STR2## 其中R为氢、较低烷基、较低烯烃基、苯基或苯基较低烷基；A为从芳香偶氮染料残基中选择的一种，通过较低烷基桥连接到季铵氮原子。K是一个小整数，其值取决于A的性质，范围为一到二；R.sup.8为较低烷基、较低烯烃基或羟基较低烷基；R.sup.9为较低烷基、羟基较低烷基或NH.sub.2；R.sup.10为较低烷基或较低烯烃基；A.sup.1为从芳香偶氮染料残基中选择的一种，通过较低烷基桥连接到季铵氮原子；G是一个小整数，其值取决于A.sup.1的性质，范围为一到二；R.sup.8 '为较低烷基；R.sup.9 '为较低烷基、较低烯烃基或羟基较低烷基；R.sup.10 '为较低烷基、较低烯烃基或羟基较低烷基或R.sup.9 '和R.sup.10 '与氮原子一起为吗啉基；A.sup.2为从芳香偶氮染料残基中选择的一种，通过较低烷基桥连接到季铵氮原子；h是一个小整数，其值取决于A.sup.2的性质，范围为一到二；An为阴离子，特别适用于染色天然纤维、合成纤维形成材料和纤维素材料。这些染料可使棉花和纸张呈现各种稳定的黄色、红色和橙色。这些染料在纸张上的染色不易渗出，漂白时与次氯酸盐或氯漂白剂一起具有高度的色彩释放度。
• Water-soluble quaternary ammonium heterocyclic azo dyestuffs
  申请人：Sterling Drug Inc.

  公开号：US03935182A1

  公开（公告）日：1976-01-27

  Water-soluble cationic dyestuffs of the formulae ##SPC1## Wherein R.sup.0 is hydrogen, lower-alkyl or hydroxy-lower-alkyl; R.sup.1 is lower-alkyl, lower-alkenyl or hydroxy-lower-alkyl; R.sup.2 is lower-alkyl, lower-alkenyl, hydroxy-lower-alkyl or -(lower-alkylene)-NRO Y or R.sup.1 and R.sup.2 together with the nitrogen atom, are pyrrolidino, piperidino or 4-lower-alkanoyl piperazino; Y is hydrogen or ##EQU1## wherein R is hydrogen, lower-alkyl, lower-alkenyl, phenyl or phenyl-lower-alkyl; A is a member selected from the group consisting of an aromatic azo dyestuff residue attached to the quaternary ammonium nitrogen atom through a lower-alkylene bridge. k is a small integer whose value is dependent on the nature or A such that it has a range from one to two; R.sup.8 is lower-alkyl, lower-alkenyl or hydroxy-lower-alkyl; R.sup.9 is lower-alkyl, hydroxy-lower-alkyl or NH.sub.2 ; R.sup.10 is lower-alkyl or lower-alkenyl; A.sup.1 is an aromatic azo dyestuff residue attached to the quaternary ammonium nitrogen atom through a lower-alkylene bridge; g is a small integer whose value is dependent on the nature of A.sup.1 such that it has a range from one to two; R.sup.8.sup.' is lower-alkyl; R.sup.9.sup.' is lower-alkyl, lower alkenyl or hydroxy-lower-alkyl; R.sup.10.sup.' is lower-alkyl, lower -alkenyl or hydroxy-lower-alkyl or R.sup.9.sup.' and R.sup.10.sup.' together with the nitrogen atom are morpholino; A.sup.2 is an aromatic azo dyestuff residue attached to the quaternary ammonium nitrogen atom through a lower-alkylene bridge; h is a small integer whose value is dependent on the nature of A.sup.2 such that it has a range from one to two; and An is an anion Are particularly useful for coloring natural fibers, synthetic fiber-forming materials and cellulosic materials.

  具有以下公式的水溶性阳离子染料：##SPC1## 其中R.sup.0是氢，低烷基或羟基低烷基；R.sup.1是低烷基，低烯基或羟基低烷基；R.sup.2是低烷基，低烯基，羟基低烷基或-(低烷基)-NRO Y或R.sup.1和R.sup.2与氮原子一起，为吡咯烷基，哌嗪基或4-低烷酰基哌嗪基；Y是氢或##EQU1## 其中R是氢，低烷基，低烯基，苯基或苯基-低烷基；A是选自由芳香偶氮染料残基的一种，通过低烷基桥连接到季铵氮原子。k是小整数，其值取决于A的性质，范围从一到二；R.sup.8是低烷基，低烯基或羟基低烷基；R.sup.9是低烷基，羟基低烷基或NH.sub.2；R.sup.10是低烷基或低烯基；A.sup.1是通过低烷基桥连接到季铵氮原子上的芳香偶氮染料残基；g是小整数，其值取决于A.sup.1的性质，范围从一到二；R.sup.8.sup.'是低烷基；R.sup.9.sup.'是低烷基，低烯基或羟基低烷基；R.sup.10.sup.'是低烷基，低烯基或羟基低烷基或R.sup.9.sup.'和R.sup.10.sup.'与氮原子一起是吗啡基；A.sup.2是通过低烷基桥连接到季铵氮原子上的芳香偶氮染料残基；h是小整数，其值取决于A.sup.2的性质，范围从一到二；An是阴离子。这些染料特别适用于着色天然纤维，合成纤维成型材料和纤维素材料。
• (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as
  申请人：Karl Thomae GmbH

  公开号：US05602127A1

  公开（公告）日：1997-02-11

  Angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo [1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: 4'-[(2-n-propyl-4-methyl-6-(butanesultam-1-yl)benzimidazol-1-yl)-methyl]-b iphenyl-2-carboxylic acid.

  公式为 ##STR1## 的血管紧张素-II受体拮抗剂，其中R.sub.1是卤素、低烷基或环烷基等，但不包括氢；R.sub.2是可选取代的苯并咪唑-2-基、5,6,7,8-四氢咪唑[1,2-a]吡啶-2-基、丁磺酰胺-1-基、咪唑-4-基和四氢苯并咪唑-2-基等；R.sub.3是低烷基等；R.sub.4是酸性基团，例如羧基或四唑基。其中一种示例化合物是：4'-[(2-n-丙基-4-甲基-6-(丁磺酰胺-1-基)苯并咪唑-1-基)-甲基]-联苯-2-羧酸。
• N,N-Dialkyl-N-aminoalkyl-N-(amino or nitro)phenylalkyl- and
  申请人：Sterling Drug Inc.

  公开号：US04206144A1

  公开（公告）日：1980-06-03

  N,N-Dialkyl-N-aminoalkyl-N-aminophenylalkyl quaternary ammonium salts and N-methyl-N-(3-aminophenoxy-2-hydroxy-1-propyl)-N,N-bis(3-aminopropyl) quaternary ammonium salts and their N-nitrophenylalkyl and N-(3-nitrophenoxy) precussor quaternary ammonium salts, respectively are intermediates to water-soluble azo-dyestuffs useful for coloring natural fibers, synthetic fiber-forming materials and cellulosic materials. These dyes dye cotton and paper various shades of yellows, reds, and oranges with less prone to bleed and with a high degree of discharge when bleached with hypochlorite or chlorine bleaches.

  N,N-二烷基-N-氨基烷基-N-氨基苯基烷基季铵盐和N-甲基-N-(3-氨基苯氧基-2-羟基-1-丙基)-N,N-双(3-氨基丙基)季铵盐以及它们的N-硝基苯基烷基和N-(3-硝基苯氧基)前体季铵盐是水溶性偶氮染料的中间体，可用于染色天然纤维、合成纤维形成材料和纤维素材料。这些染料可使棉和纸以不同的黄、红和橙色染色，不易褪色，在次氯酸或氯漂白剂漂白时具有高度的脱色能力。