N-(2-(二甲氨基)乙基)-2-溴异丁酰胺 | 734505-23-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(2-(二甲氨基)乙基)-2-溴异丁酰胺
• 英文名称: N-(2-(dimethylamino)ethyl)-2-bromoisobutyramide
• 英文别名: 2-(dimethylamino)ethyl-2-bromoisobutyrylamide；N-(dimethylaminoethyl)-2-bromoisobutyrylamide；2-bromo-N-[2-(dimethylamino)ethyl]-2-methylpropanamide
• CAS: 734505-23-8
• 化学式: C₈H₁₇BrN₂O
• 分子量: 237.14
• InChiKey: UHKMJGOFGKRVFL-UHFFFAOYSA-N

物化性质

• 沸点：
  313.5±27.0 °C(Predicted)
• 密度：
  1.268±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-2-甲基丙酰溴 、 1,2-二氨基-2-甲基丙烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以72%的产率得到N-(2-(二甲氨基)乙基)-2-溴异丁酰胺
  参考文献：
  名称：

  新型多元酸稳定乳胶的合成与表征

  摘要：

  通过原子转移自由基聚合反应（ATRP），通过两步法制备了一系列基于甲基丙烯酸2-羟丙酯（HPMA）的新型多元酸大分子单体。首先，使用叔胺官能化的引发剂，2-（二甲氨基）乙基-2-溴异丁酰胺和CuCl / 2，2'-联吡啶（bpy）催化剂通过ATRP合成了一系列定义明确的PHPMA均聚物前体介质在50°C下。在纯异丙醇（IPA）中，ATRP的聚合反应相对较慢且控制不佳，尤其是在针对更高聚合度的情况下（DP> 30）。通过添加水实现了更好的控制：低多分散度（M w / M n<1.25）在50°C下使用9：1 w / w％IPA /水混合物成功制备了DP = 30、40、50、60或70的PHPMA均聚物。然后通过将叔胺端基与过量的4-乙烯基苄基氯季铵化，然后将这些PHPMA均聚物前体衍生化，生成相应的聚（2-（琥珀酰氧基）丙基甲基丙烯酸）（PSPMA）大分子单体，然后使用过量的侧基进行酯化琥

  DOI：

  10.1021/la302657x

文献信息

• From well-defined macromonomers to sterically-stabilised latexes to covalently cross-linkable colloidosomes: exerting control over multiple length scales
  作者：Kate L. Thompson、Steven P. Armes

  DOI：10.1039/c0cc01362e

  日期：——

  A new route to covalently cross-linkable colloidosomes has been developed via the assembly of sterically stabilised latex particles onto oil droplets. These latexes can be cross-linked from within the oil droplets via the steric stabiliser chains on the inner-particle surface using an oil-soluble polymeric diisocyanate. Such microcapsules can survive both surfactant and alcohol challenges.

  通过在油滴上组装立体稳定胶乳颗粒，开发出了一种可共价交联胶体的新途径。使用油溶性聚合二异氰酸酯，可通过内颗粒表面的立体稳定剂链从油滴内部交联这些胶乳。这种微胶囊可以经受表面活性剂和酒精的考验。
• Preparation of Biocompatible Sterically Stabilized Latexes Using Well-Defined Poly(2-(methacryloyloxy)ethyl phosphorylcholine) Macromonomers
  作者：Kate L. Thompson、Iveta Bannister、Steven P. Armes、Andrew L. Lewis

  DOI：10.1021/la903567q

  日期：2010.4.6

  for successful latex formation. FTIR spectroscopy indicated the presence of the PMPC30 macromonomer within the polystyrene latex, and XPS studies indicated that these stabilizer chains are located at (or very near) the latex surface, as expected. Using PMPC20 and PMPC10 macromonomers for the alcoholic dispersion polymerization of styrene led to latexes with substantially broader size distributions compared

  使用2-（二甲基氨基）乙基-2-溴异丁酰胺在醇介质中通过原子转移自由基聚合（ATRP）合成了一系列基于仿生单体2-（甲基丙烯酰氧基）乙基磷酸胆碱（MPC）的明确定义的甲基丙烯酸大分子单体。该叔胺官能化的引发剂用于通过ATRP生产各种链长的均聚物前体。这些聚合反应相对良好控制（中号瓦特/中号Ñ ≤1.30），条件是聚合的目标度（DP）不超过30。更高的目标DPS，聚合控制很差并且其特征在于宽分子量分布（中号w ^ /中号ñ= 1.50-2.31）。然后使用4-乙烯基苄基氯（4-VBC）将每个几乎单分散的均聚物前体的叔胺端基季铵化，得到相应的苯乙烯官能化的大分子单体。PMPC 30大分子单体被证明是有效的反应性空间稳定剂，当以苯乙烯单体为基准以10 w / w％的比例使用时，可形成聚苯乙烯胶乳。通过扫描电子显微镜和动态光散射研究判断，分别通过水乳液和醇分散聚合制备了近单分散的亚微米级和微米级的
• Synthesis of Sterically-Stabilized Latexes Using Well-Defined Poly(glycerol monomethacrylate) Macromonomers
  作者：K. L. Thompson、S. P. Armes、D. W. York、J. A. Burdis

  DOI：10.1021/ma9027799

  日期：2010.3.9

  A range of well-defined methacrylic macromonomers based oil glycerol monomethacrylate (GMA) has been synthesized by atom transfer radical polymerization (ATRP) in alcoholic media using an N-(dimethylamino)ethyl-2-bromioisobutyrylamide initiator. This tertiary amine-functionalized initiator was used to produce six homopolymer precursors with target degrees of polymerization of 20, 30, 40, 50, 60, and 70 via ATRP. These polymerizations proceeded to very high conversions (> 95%) and afforded relatively low polydispersities (M-w/M-n <= 1.33). The tertiary amine end groups were then quaternized using 4-vinylbenzyl chloride (4-VBC) to afford the corresponding near-monodisperse styrene-functionalized PGMA macromonomers. These PGMA macromonomers were evaluated as reactive steric stabilizers for latex syntheses. Near-monodisperse submicrometer-sized and micrometer-sized polystyrene latexes were obtained by aqueous emulsion and alcoholic dispersion polymerization, respectively, as judged by scanning electron microscopy and dynamic light scattering studies. Attempted latex syntheses conducted in the absence of any macromonomer invariably resulted in macroscopic precipitation under dispersion polymerization conditions, with no evidence of latex formation. Higher molecular weight macromonomers (DP = 40 or 50) generally gave smaller, more monodisperse particles compared with the lower molecular weight macromonomers (DP = 20 or 30). Latex syntheses conducted in the presence of the PGMA(50) homopolymer precursor produced particles with significantly larger diameters than those prepared with the corresponding styrene-functionalized PGMA(50) macromonomer. Such control experiments confirmed the importance of having terminal styrene groups oil the macromonomer chains for successful latex formation. FT-IR spectroscopy indicated the presence of the PGMA(50) macromonomer within the polystyrene latex and XPS studies indicated that these stabilizer chains are located at (or very near) the latex surface, as expected. Finally, approximately micrometer-sized latexes can be produced by aqueous dispersion polymerization of 2-hydroxypropyl methacrylaic in the presence of the PGMA(50) macromonomer.
• [EN] LIQUID COMPOSITE MATERIALS<br/>[FR] MATÉRIAUX COMPOSITES LIQUIDES
  申请人：UNIV SHEFFIELD

  公开号：WO2010092191A2

  公开（公告）日：2010-08-19

  A composite material or structure comprising a body of liquid and a hydrophobic coating material entirely surrounding the liquid. At least one property of the coating material changes on application of an external stimulus to the composite material or structure. Preferably the coating material is a polymeric material including functional groups (Z) which change in response to the external stimulus applied to the composite material or structure, thereby changing a property of the coating material. An example of the external stimulus is a change in pH of the environment in which the composite material or structure is located.