2-N,N-Dibenzyl Serine Benzyl Ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-N,N-Dibenzyl Serine Benzyl Ester
• 英文别名: benzyl 2-(dibenzylamino)-3-hydroxypropanoate
• 化学式: C₂₄H₂₅NO₃
• mdl: MFCD02093744
• 分子量: 375.5
• InChiKey: IZGCKWHDNJEEAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.208
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE FLUOROAMINE
  申请人：Central Glass Company, Limited

  公开号：EP2243769B1

  公开（公告）日：2017-06-28
• MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
  申请人：Gilead Sciences, Inc.

  公开号：EP2861604B1

  公开（公告）日：2017-03-01
• Process for Producing Alpha-Fluoro-Beta-Amino Acids
  申请人：Ishii Akihiro

  公开号：US20110015428A1

  公开（公告）日：2011-01-20

  By reacting a β-hydroxy-α-amino acid with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base, it is possible to produce an α-fluoro-β-amino acid of the formula [2]. By using a C8-12 tertiary amine having two or more alkyl groups of C3 or higher, and especially diisopropylethylamine, as the organic base, by-production of quantery ammonium salts is effectively suppressed. By applying the production process of the present invention, it is possible to very easily produce (2R)-3-(dibenzylamino)-2-fluoropropionic acid methyl ester, which is extremely important as a pharmaceutical intermediate, with high positional selectivity even on an industrial scale.
• Process for Production of Optically Active Fluoroamine
  申请人：Ishii Akihiro

  公开号：US20110034732A1

  公开（公告）日：2011-02-10

  Disclosed is a process for producing a protected optically active fluoroamine, which comprises the step of reacting an imine-protected optically active hydroxyamine, an oxazolidine-protected optically active hydroxyamine, or a mixture of the imine-protected optically active hydroxyamine and the oxazolidine-protected optically active hydroxyamine, with sulfuryl fluoride (SO 2 F 2 ) in the presence of a tertiary amine having a carbon number of 7 to 18 (produced by substituting all of three hydrogen atoms in ammonia by alkyl groups). The desired optically active fluoroamine can be produced by hydrolyzing the protected optically active fluoroamine under acidic conditions.
• US8217196B2
  申请人：——

  公开号：US8217196B2

  公开（公告）日：2012-07-10