3-[[2-[[2-azaniumyl-5-(diaminomethylideneazaniumyl)pentanoyl]amino]acetyl]amino]-4-[(1-carboxylato-2-hydroxyethyl)amino]-4-oxobutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[[2-[[2-azaniumyl-5-(diaminomethylideneazaniumyl)pentanoyl]amino]acetyl]amino]-4-[(1-carboxylato-2-hydroxyethyl)amino]-4-oxobutanoate
• 化学式: C15H27N7O8
• 分子量: 433.42
• InChiKey: NNRFRJQMBSBXGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.3
• 重原子数：
  30
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  273
• 氢给体数：
  9
• 氢受体数：
  10

文献信息

• CROSSLINKED POLY-DEPSIPEPTIDE COPOLYMERS AND METHODS OF MAKING THEREOF
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20160083516A1

  公开（公告）日：2016-03-24

  Aspects of the present disclosure include methods for preparing crosslinked polydepsipeptide copolymers by stereolithography (e.g., 3-D printing). In practicing methods according to certain embodiments, a crosslinkable copolymer containing a depsipeptide having one or more hydrolysable crosslinkers is photocrosslinked by stereolithography to produce a crosslinked polydepsipeptide copolymer. In certain embodiments, methods include contacting the crosslinkable poly(depsipeptide-co-ε-caprolactone) copolymer precursor with one or more bioactive agents and photocrosslinking by 3-D printing to produce a crosslinked poly(depsipeptide-co-ε-caprolactone) copolymer with incorporated bioactive agent. Crosslinkable polydepsipeptide copolymer precursors and crosslinked polydepsipeptide copolymers are also described.

  本公开的方面包括通过光立体造型（例如，3D打印）制备交联聚脱氨肽共聚物的方法。在根据某些实施方式实施方法时，通过光立体造型交联含有一个或多个可水解交联剂的脱氨肽的共聚物，以产生交联聚脱氨肽共聚物。在某些实施方式中，方法包括将可交联的聚脱氨肽-co-ε-己内酯共聚物前体与一个或多个生物活性剂接触，并通过3D打印进行光交联，以产生具有内含生物活性剂的交联聚脱氨肽-co-ε-己内酯共聚物。还描述了可交联的聚脱氨肽共聚物前体和交联的聚脱氨肽共聚物。
• Chelate based scaffolds in tumor targeting
  申请人：Garlich R. Joseph

  公开号：US20070104645A1

  公开（公告）日：2007-05-10

  This invention relates to novel complexes that can be used to target tumor cells. The complexes include a ligand that can bind metal ions including radioactive lanthanide ions. The complexes can mimic α ν β3 integrin receptor antagonists and deliver the complexed radioactive metals to the tumor cells.
• PI-3 KINASE INHIBITOR PRODRUGS
  申请人：Garlich Joseph R.

  公开号：US20080188423A1

  公开（公告）日：2008-08-07

  The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.
• US7396828B2
  申请人：——

  公开号：US7396828B2

  公开（公告）日：2008-07-08
• US7662977B2
  申请人：——

  公开号：US7662977B2

  公开（公告）日：2010-02-16