2-bromo-1-(2-ethoxy-5-(4-methoxyphenyl)furan-3-yl)-2,2-difluoroethanone | 1215897-56-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-bromo-1-(2-ethoxy-5-(4-methoxyphenyl)furan-3-yl)-2,2-difluoroethanone
• CAS: 1215897-56-5
• 化学式: C₁₅H₁₃BrF₂O₄
• 分子量: 375.167
• InChiKey: QWLCDQZWVSZGEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.52
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  48.67
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  4-乙炔基苯甲醚 、 4-Bromo-2-diazo-4,4-difluoro-3-oxo-butyric acid ethyl ester 在 rhodium(II) acetate dimer 作用下， 以 二氯甲烷 为溶剂， 以15%的产率得到2-bromo-1-(2-ethoxy-5-(4-methoxyphenyl)furan-3-yl)-2,2-difluoroethanone
  参考文献：
  名称：

  Rh2(OAc)4 catalyzed formation of fluorine-containing polysubstituted furans from diazocompounds and aromatic alkynes

  摘要：

  A new building block strategy for the synthesis Of fluorine-containing 1,2,4-trisubstituted furan was reported The 1,2,4-trisubstituted furan was constructed through [3+2] cycloaddition reaction of fluoroacetyl-containing diazocompound and aromatic alkyne, catalyzed by Rh-2(OAc)(4) (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.015

文献信息

• Rh2(OAc)4 catalyzed formation of fluorine-containing polysubstituted furans from diazocompounds and aromatic alkynes
  作者：Wan Pang、Shifa Zhu、Yong Xin、Huanfeng Jiang、Shizheng Zhu

  DOI：10.1016/j.tet.2009.12.015

  日期：2010.2

  A new building block strategy for the synthesis Of fluorine-containing 1,2,4-trisubstituted furan was reported The 1,2,4-trisubstituted furan was constructed through [3+2] cycloaddition reaction of fluoroacetyl-containing diazocompound and aromatic alkyne, catalyzed by Rh-2(OAc)(4) (C) 2009 Elsevier Ltd All rights reserved