4-hydroxamido-N-methylpyridinium iodide | 89970-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-hydroxamido-N-methylpyridinium iodide
• 英文别名: 4-hydroxycarbamoyl-1-methyl-pyridinium; iodide；4-Hydroxycarbamoyl-1-methyl-pyridinium; Jodid；Isonicotinohydroxamsaeure-methojodid；4-Hydroxycarbamoyl-1-methylpyridinium iodide；N-hydroxy-1-methylpyridin-1-ium-4-carboxamide;iodide
• CAS: 89970-81-0
• 化学式: C₇H₉N₂O₂*I
• 分子量: 280.065
• InChiKey: YUFAVDQPVKFRDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.37
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  53.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异烟酸乙酯 在 羟胺 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 20.0h， 生成 4-hydroxamido-N-methylpyridinium iodide
  参考文献：
  名称：

  Lion, C.; Hedayatullah, M.; Bauer, P., Bulletin des Societes Chimiques Belges, 1991, vol. 100, # 8, p. 617 - 621

  摘要：

  DOI：

文献信息

• SELECTIVE PLACEMENT OF CARBON NANOTUBES VIA COULOMBIC ATTRACTION OF OPPOSITELY CHARGED CARBON NANOTUBES AND SELF-ASSEMBLED MONOLAYERS
  申请人：International Business Machines Corporation

  公开号：US20160137605A1

  公开（公告）日：2016-05-19

  A method of forming a structure having selectively placed carbon nanotubes, a method of making charged carbon nanotubes, a bi-functional precursor, and a structure having a high density carbon nanotube layer with minimal bundling. Carbon nanotubes are selectively placed on a substrate having two regions. The first region has an isoelectric point exceeding the second region's isoelectric point. The substrate is immersed in a solution of a bi-functional precursor having anchoring and charged ends. The anchoring end bonds to the first region to form a self-assembled monolayer having a charged end. The substrate with charged monolayer is immersed in a solution of carbon nanotubes having an opposite charge to form a carbon nanotube layer on the self-assembled monolayer. The charged carbon nanotubes are made by functionalization or coating with an ionic surfactant.

  一种形成具有选择性放置碳纳米管的结构的方法，一种制备带电碳纳米管的方法，一种双功能前体，以及具有高密度碳纳米管层且最小捆绑的结构。碳纳米管被选择性地放置在具有两个区域的基底上。第一个区域的等电点超过第二个区域的等电点。基底浸入具有锚定端和带电端的双功能前体溶液中。锚定端与第一个区域结合形成具有带电端的自组装单分子层。带有带电单分子层的基底浸入具有与其带电相反的电荷的碳纳米管溶液中，形成碳纳米管层在自组装单分子层上。带电碳纳米管通过功能化或涂覆离子表面活性剂而制备。
• Fluorosulfate as a Latent Sulfate in Peptides and Proteins
  作者：Chao Liu、Xueyi Liu、Mi Zhou、Chaoshuang Xia、Yuhan Lyu、Qianni Peng、Chintan Soni、Zefeng Zhou、Qiwen Su、Yujia Wu、Eranthie Weerapana、Jianmin Gao、Abhishek Chatterjee、Cheng Lin、Jia Niu

  DOI：10.1021/jacs.3c07937

  日期：2023.9.20

  understanding the biological functions of sulfation in peptides and proteins has been hampered by the lack of methods to control its spatial or temporal distribution in the proteome. Herein, we report that fluorosulfate can serve as a latent precursor of sulfate in peptides and proteins, which can be efficiently converted to sulfate by hydroxamic acid reagents under physiologically relevant conditions. Photocaging

  硫酸化广泛存在于真核蛋白质组中。然而，由于缺乏控制其在蛋白质组中的空间或时间分布的方法，对肽和蛋白质中硫酸化的生物学功能的理解受到了阻碍。在此，我们报道氟硫酸盐可以作为肽和蛋白质中硫酸盐的潜在前体，在生理相关条件下可以通过异羟肟酸试剂有效地转化为硫酸盐。光笼罩异羟肟酸试剂进一步实现了功能性磺肽的光控激活。这项工作为探索硫酸化在肽和蛋白质中的功能作用提供了一个有价值的工具。
• Acceleration of the Hydrolysis of Organic Fluorophosphates and Fluorophosphonates with Hydroxamic Acids
  作者：B. E. Hackley、R. Plapinger、M. Stolberg、T. Wagner-Jauregg

  DOI：10.1021/ja01618a072

  日期：1955.7
• Lion, C.; Hedayatullah, M.; Bauer, P., Bulletin des Societes Chimiques Belges, 1991, vol. 100, # 8, p. 617 - 621
  作者：Lion, C.、Hedayatullah, M.、Bauer, P.、Boukou-Poba, J. P.、Charvy, C.、et al.

  DOI：——

  日期：——