Glutamin-benzylester | 66449-94-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glutamin-benzylester
• 英文别名: Benzyl glutaminate；benzyl 2,5-diamino-5-oxopentanoate
• CAS: 66449-94-3
• 化学式: C₁₂H₁₆N₂O₃
• 分子量: 236.271
• InChiKey: MKDLWJQJYMMDJR-UHFFFAOYSA-N

物化性质

• 沸点：
  448.9±40.0 °C(Predicted)
• 密度：
  1.201±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  95.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID
  申请人：Kong Xianqi

  公开号：US20080146642A1

  公开（公告）日：2008-06-19

  The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to, the prevention and treatment of Alzheimer's disease.

  这项发明涉及用于在受试者中（最好是人类受试者）传递3-氨基-1-丙磺酸（3APS）的方法、化合物、组合物和载体。该发明涵盖将产生或生成3APS的化合物，无论是在体外还是体内。首选的化合物包括3APS的氨基酸前药，用于预防和治疗阿尔茨海默病等用途。
• Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
  申请人：BHI Limited Partnership

  公开号：EP2862581A2

  公开（公告）日：2015-04-22

  The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1 -propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to, the prevention and treatment of Alzheimer's disease.

  本发明涉及向受试者（最好是人类受试者）提供 3-氨基-1-丙磺酸（3APS）的方法、化合物、组合物和载体。本发明包括在体外或体内产生或生成 3APS 的化合物。优选的化合物包括 3APS 的氨基酸原药，其用途包括但不限于预防和治疗阿尔茨海默病。
• Methods for treating neurological disorders
  申请人：Alzheon, Inc.

  公开号：US10471029B2

  公开（公告）日：2019-11-12

  Disclosed herein are methods and compositions for treating, ameliorating, and/or preventing Alzheimer's disease in ApoE4-postitive patients using particular compounds and compositions thereof.

  本文公开了使用特定化合物及其组合物治疗、改善和/或预防载脂蛋白E4阳性患者阿尔茨海默病的方法和组合物。
• Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same, for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory, and for the treatment of coma
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0514359B1

  公开（公告）日：1995-09-13
• CYANOPHOSPHORUS COMPOUNDS AND THEIR PREPARATION
  申请人：MONSANTO COMPANY

  公开号：EP0948502A1

  公开（公告）日：1999-10-13