N-Acryloyl-DL-phenylalanin | 10324-82-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acryloyl-DL-phenylalanin
• 英文别名: N-acrylphenylalanine；N-acryloylphenylalanine；APhe；3-phenyl-2-(prop-2-enoylamino)propanoic acid
• CAS: 10324-82-0
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: XFHQGYBXSCRMNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Acryloyl-DL-phenylalanin 在 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 4.0h， 生成 2-(4-benzyl-2-vinyloxazol-5-yl)acetonitrile
  参考文献：
  名称：

  由N-酰基氨基酸通过N，N'-二异丙基碳二亚酰亚胺的环脱水和Wittig烯烃的结合一锅法合成2,4,5-三取代的恶唑。

  摘要：

  通过环化脱水的的组合ñ -酰基氨基酸与Ñ，Ñ '-diisopropylcarbodiimide（DIC）和所得到的5（4的非经典Wittig烯ħ）-oxazolones的Ph 3 P CHCN且Ph 3 P CHCOOEt，5-一锅合成恶唑乙腈和5-恶唑乙酸盐，产率分别为41-85％和57-70％。

  DOI：

  10.1016/j.tet.2011.12.004
• 作为产物：
  描述：

  DL-苯丙氨酸 、 丙烯酰氯 生成 N-Acryloyl-DL-phenylalanin
  参考文献：
  名称：

  Interaction of poly(N-acryloyl-amino acids) with saccharides in aqueous media

  摘要：

  The interaction of a series of poly(N-acryloyl-amino acids) (pAXaa) with saccharides has been investigated by (1)H NMR (1)H NMR for methyl-beta-D-galactopyranoside (M beta Gal) in the presence of pAXaa indicated that hydrophobic interaction or hydrogen bonding was not considerable in the interaction of the polymers with M beta Gal in aqueous media whereas CH-pi interaction was relatively important. (1)H NMR for several saccharides in the presence of poly(N-acryloyltryptophan) (pATrp) indicated that pATrp interacted more strongly with the beta-anomers than with the alpha-anomers presumably because of the triple CH-pi interactions of the three axial protons in the beta-anomers. In the interaction of pATrp with M beta Gal, M beta Gal interacted with two or more Trp residues because Trp residues were localized on the polymer chain. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2009.10.070

文献信息

• [EN] HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE<br/>[FR] PYRROLOPYRIDINES À SUBSTITUTION HÉTÉROCYCLYLE UTILISÉES EN TANT QU'INHIBITEURS DE LA KINASE CDK12
  申请人：UNIV NOTTINGHAM

  公开号：WO2019058132A1

  公开（公告）日：2019-03-28

  This invention relates to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular,the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

  这项发明涉及抑制CDK12激酶的化合物。这些化合物可用于治疗由CDK12激酶介导的疾病，包括1型肌强直性营养不良（DM1）和其他由RNA重复扩展转录物引起的疾病。特别是，该发明涉及公式（I）的化合物，或其药用可接受的盐或N-氧化物，其中R1a, R2, R3, R4a, R4b和R4c按本文定义。
• [EN] PROCESSES FOR SEPARATING AGGREGATED PROTEINS FROM MONOMERIC PROTEINS IN A BIOLOGICAL SOLUTION<br/>[FR] PROCÉDÉS DE SÉPARATION DE PROTÉINES AGRÉGÉES À PARTIR DE PROTÉINES MONOMÈRES DANS UNE SOLUTION BIOLOGIQUE
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2018048698A1

  公开（公告）日：2018-03-15

  A process for separating aggregated proteins from monomeric proteins in a biological solution, the process including: providing at least one filter element having a contacting surface, wherein the filter element comprises filter media comprising: a porous substrate; and disposed on the porous substrate, a polymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein each of a first plurality of pendant groups comprises: (1) at least one acidic group or salt thereof; and (2) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and allowing an initial biological solution to contact the contacting surface of the filter element under conditions effective to separate the aggregated proteins from the monomeric proteins such that a final biological solution includes purified monomeric proteins.

  一种从生物溶液中分离聚集蛋白质和单体蛋白质的方法，该方法包括：提供至少一个具有接触表面的过滤元件，其中过滤元件包括包括过滤介质的多孔基质；并且在多孔基质上设置了一种聚合物，该聚合物包括一个烃骨架和附着在烃骨架上的多个偏基团，其中第一多个偏基团中的每一个包括：（1）至少一个酸性基团或其盐；和（2）一个间隔基团，通过至少6个串联原子的链将至少一个酸性基团或其盐直接连接到烃骨架；并且允许初始生物溶液在有效条件下接触过滤元件的接触表面，以使聚集蛋白质与单体蛋白质分离，从而得到含有纯化单体蛋白质的最终生物溶液。
• [EN] NEUTRALIZING VENOMOUS BIOMACROMOLECULES<br/>[FR] NEUTRALISATION DE BIOMACROMOLÉCULES DE VENIN
  申请人：UNIV CALIFORNIA

  公开号：WO2018112313A1

  公开（公告）日：2018-06-21

  The present invention relates generally to compositions and methods comprising abiotic, synthetic polymer nanoparticles (NPs) with affinity and specificity to peptide toxins, enzymes, signaling proteins and other large biomacromolecules. The synthetic polymer NPs are an improvement over the current art due to insusceptibility to phospholipase attack, a mechanism common to many venoms. In one embodiment, the compositions and methods relate to synthetic polymer NPs with affinity and specificity to three finger toxins (3FTX) and phospholipase A2. In one embodiment, the compositions and methods are useful for delaying or preventing tissue necrosis due to envenomation.

  本发明涉及包括无生物合成聚合物纳米粒子（NPs）的组合物和方法，其具有亲和力和特异性，可用于肽毒素、酶、信号蛋白和其他大型生物大分子。由于对磷脂酶攻击不敏感，合成聚合物NPs是当前技术的改进。在一种实施例中，所述组合物和方法涉及具有亲和力和特异性的合成聚合物NPs，用于三指毒素（3FTX）和磷脂酶A2。在一种实施例中，所述组合物和方法可用于延迟或预防因蛇咬而导致的组织坏死。
• New Alkali Soluble Resin
  申请人：Loccufier Johan

  公开号：US20110247516A1

  公开（公告）日：2011-10-13

  An alkali soluble resin is disclosed comprising a first monomeric unit including at least one sulfonamide group and a second monomeric unit derived from the monomer according to the following structure (I) wherein R 1 represents a structural moiety comprising an ethylenically unsaturated polymerisable group; R 2 , R 3 and R 4 independently represent hydrogen, an optionally substituted alkyl, alkenyl, alkynyl, alkaryl, aralkyl, aryl or heteroaryl group or, the necessary atoms to form a five to eight membered ring.

  揭示了一种碱溶性树脂，包括第一单体单元，其中包括至少一个磺酰胺基团和从具有以下结构（I）的单体得到的第二单体单元，其中R1表示包括乙烯基不饱和可聚合基团的结构基团; R2、R3和R4独立地表示氢、可选地取代的烷基、烯基、炔基、烷基芳基、芳基烷基、芳基或杂环芳基基团或形成五至八元环所必需的原子。
• A new alkali soluble resin
  申请人：Agfa Graphics N.V.

  公开号：EP2213690A1

  公开（公告）日：2010-08-04

  An alkali soluble resin is disclosed comprising a first monomeric unit including at least one sulfonamide group and a second monomeric unit derived from the monomer according to the following structure: wherein R1 represents a structural moiety comprising an ethylenically unsatured polymerisable group; R2, R3 and R4 independently represent hydrogen, an optionally substituted alkyl, alkenyl, alkynyl, alkaryl, aralkyl, aryl or heteroaryl group or, the necessary atoms to form a five to eight membered ring.

  本发明公开了一种碱溶性树脂，该树脂由包含至少一个磺酰胺基团的第一单体单元和按以下结构衍生的第二单体单元组成： 其中 R1 代表包含乙烯不成熟可聚合基团的结构分子； R2、R3 和 R4 独立地代表氢、任选取代的烷基、烯基、炔基、烷芳基、芳烷基、芳基或杂芳基或形成五至八分子环所需的原子。