N-(2-氯苯基)-2-羟基苯甲酰胺 | 1697-18-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2-氯苯基)-2-羟基苯甲酰胺
• 英文名称: 2-hydroxybenzoyl-N-(2-chlorophenyl)amide
• 英文别名: N-(2-chlorophenyl)-2-hydroxybenzamide；N-salicylo-2-chloroaniline；2'-Chlorosalicylanilide；N-(2-chloro-phenyl)-2-hydroxy-benzamide；salicylic acid-(2-chloro-anilide)；Salicylsaeure-(2-chlor-anilid)
• CAS: 1697-18-3
• 化学式: C₁₃H₁₀ClNO₂
• mdl: MFCD00624483
• 分子量: 247.681
• InChiKey: KFIQAGIXMXTUIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  4-氯甲基吡啶 、 N-(2-氯苯基)-2-羟基苯甲酰胺 在 氢氧化钾 作用下， 以 水 为溶剂， 以20%的产率得到N-(2-chlorophenyl)-2-(pyridin-4-ylmethoxy)benzamide
  参考文献：
  名称：

  Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases

  摘要：

  A series of benzamidines and benzamides was synthesized as selective inhibitors of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, and tested for inhibitory activity toward autophosphorylation by the enzyme assay. Selective inhibition of VEGFR-2 tyrosine kinase was observed in the salicylic amide 4e and the anthranilic amidine 5a, and their percent inhibitions of VEGFR-2 tyrosine kinase were 44-60% at a 10 mu M concentration of compounds. The salicylic amide 4a showed inhibition of both VEGFR-1 and VEGFR-2 tyrosine kinases at a 10 mu M concentration. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.075
• 作为产物：
  描述：

  邻乙酰水杨酰氯 在 sodium hydroxide 作用下， 以 丙酮 为溶剂， 反应 1.5h， 生成 N-(2-氯苯基)-2-羟基苯甲酰胺
  参考文献：
  名称：

  Ayyangar, N. R.; Kalkote, U. R.; Nikrad, P. V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 9, p. 872 - 877

  摘要：

  DOI：

文献信息

• PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES
  申请人：Semple J. Edward

  公开号：US20120108592A1

  公开（公告）日：2012-05-03

  A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.

  描述了一类新的水杨酰苯胺类化合物。这些化合物对肝炎病毒表现出强大的活性。
• Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase
  作者：Zhen-Wei Zhu、Lei Shi、Xiao-Ming Ruan、Ying Yang、Huan-Qiu Li、Suo-Ping Xu、Hai-Liang Zhu

  DOI：10.3109/14756361003671060

  日期：2011.2.1

  A series of salicylanilide derivatives (compounds 1--32) were synthesised by reacting substituted salicylic acids and anilines. The chemical structures of these compounds were determined by
• Wagner; Singer; Weuffen, Pharmazie, 1966, vol. 21, # 3, p. 161 - 166
  作者：Wagner、Singer、Weuffen

  DOI：——

  日期：——
• Michnowskaja et al., 1958, vol. 23, # 9, p. 35,36
  作者：Michnowskaja et al.

  DOI：——

  日期：——
• Novel orthohalogenation reaction. Synthesis of orthochloroarylamines from nitroarenes.
  作者：Nagaraj R. Ayyangar、Uttam R. Kalkote、Pandurang V. Nikrad

  DOI：10.1016/s0040-4039(00)87031-8

  日期：1982.1

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