folic acid | 64536-00-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: folic acid
• 英文别名: N-pteroyl-DL-aspartic acid；N-Pteroyl-DL-asparaginsaeure；Pteroyl-L-(+)-aspartic acid；2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]butanedioic acid
• CAS: 64536-00-1
• 化学式: C₁₈H₁₇N₇O₆
• 分子量: 427.376
• InChiKey: VKLXENVTLKYHFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  209
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  folic acid 、 乙醇 在 Amberlite 、 IR-120 resin 作用下， 反应 20.0h， 生成 folic acid diethyl ester
  参考文献：
  名称：

  Phosphorescence studies of folate

  摘要：

  A room temperature phosphorescence analysis of folate was developed, resulting in the construction of a linear calibration curve within the range of 60-1000 ng. Relative standard deviations were approximately 2% for triplicate measurements. The phosphorescence properties of analytically pure folic acid were evaluated at 77 and 298 K on a sodium acetate-impregnated paper support and on other media. Evidence is presented to support the existence of an intricate intramolecular energy transfer scheme within the folate molecule. Our results indicate that only the pterin ring system within folate appears to yield phosphorescence when studied on a sodium acetate-impregnated paper support or in aqueous alcoholic rigid glasses. The specific phosphorescent properties of a series of folate constituents are also described. Some of the results presented within this paper are in contrast to earlier reports on the phosphorescence properties of folate, and explanations for these discrepancies are provided.

  DOI：

  10.1016/0584-8539(94)80168-1

文献信息

• Controlled synthesis of MnFe2O4 nanoparticles and Gd complex-based nanocomposites as tunable and enhanced T1/T2-weighted MRI contrast agents
  作者：Zhiyi Wang、Jian Liu、Tianrong Li、Jing Liu、Baodui Wang

  DOI：10.1039/c4tb00342j

  日期：——

  Successful development of magnetic nanoparticles (MNPs) with optimal size, shape, and composition is very desirable because they would increase the image contrast of magnetic resonance imaging (MRI). Here, we report a new precursor-mediated growth process of monodisperse MnFe2O4 NPs with controlled size and shape. MnFe2O4 NPs with plate-like shapes, spherical, and cubic can be successfully prepared by simply tuning the amount of Fe(acac)3 and Mn(acac)2 in oleic acid. Magnetism and MR properties of the particles were found to depend on their size and shape. These MnFe2O4 NPs, when conjugated with gadolinium and folic acid (FA), showed a simultaneous bright signal enhancement on the T1-weighted images and significant signal reduction on the T2-weighted image. In vitro MR imaging experiments also show that the developed multifunctional Gd:FA-DTPA-PEG-DIB-MnFe2O4 NPs enable targeted dual-contrast T1- and T2-weighted MR imaging of tumor cells over-expresses the folate receptor in vitro, and the T1- and T2-weighted MRI has been greatly improved. Our results clearly indicate that such an approach of forming multifunctional Gd:FA-DTPA-PEG-DIB-MnFe2O4 NPs is of great significance for T1- and T2-weighted MR imaging of specific cancer cells with high accuracy.

  成功开发出具有最佳尺寸、形状和成分的磁性纳米粒子（MNPs）是非常理想的，因为它们可以提高磁共振成像（MRI）的图像对比度。在此，我们报告了一种新的前驱体介导的具有可控尺寸和形状的单分散 MnFe2O4 NPs 生长过程。只需调整油酸中 Fe(acac)3 和 Mn(acac)2 的含量，就能成功制备出板状、球状和立方体的 MnFe2O4 NPs。研究发现，颗粒的磁性和磁共振特性取决于它们的尺寸和形状。当这些 MnFe2O4 NPs 与钆和叶酸（FA）共轭时，在 T1 加权图像上同时显示出明亮的信号增强，而在 T2 加权图像上则显示出明显的信号减弱。体外磁共振成像实验也表明，所开发的多功能 Gd:FA-DTPA-PEG-DIB-MnFe2O4 NPs 可对体外过度表达叶酸受体的肿瘤细胞进行有针对性的 T1 和 T2 加权双对比磁共振成像，并且 T1 和 T2 加权磁共振成像得到了极大的改善。我们的研究结果清楚地表明，这种形成多功能 Gd:FA-DTPA-PEG-DIB-MnFe2O4 NPs 的方法对于高精度地对特定癌细胞进行 T1 和 T2 加权磁共振成像具有重要意义。